骨关节炎患者胫股关节软骨的mri改变及意义

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1、骨关节炎患者胫股关节面软骨的MRI改变及意义摘要目的探讨膝关节骨关节炎患者胫股关节软骨的磁共振影像学变化，为骨关节炎的诊疗提供指导和参考。方法对24例早期骨关节炎患者、20例晚期骨关节炎患者患侧膝关节及20例健康志愿者膝关节进行磁共振扫描，患者水平仰卧于磁共振扫描野内，并从足底增加10千克压力，flash序列进行冠状位扫描，获得整个胫股关节的磁共振影像，测量每个断层图像的软骨接触长度，根据层厚累计得出关节软骨面积及软骨接触面积，在中心层面测量受力区与非受力区软骨厚度。对数据进行男女性别比较及分组比较。结果男女性早期骨关节炎患者胫股关节软骨接触面积分别是47

2、．50±4．33mm2、41．10±5．90mm2，较健康对照组显著减小(P<0．01)，上述指标在晚期骨关节炎患者升高，接近正常水平。晚期骨关节炎患者胫股关节受力区软骨厚度显著变小，非受力区软骨厚度显著增加(P

3、38189TibiofemoralarticularcartilagechangeandsignltlcanceinMRIObjectiveofpatientswithosteoarthritisToinvestigatethearticularcartilagechangesofmagneticresonanceimaginginpatientswithkneeosteoarthritis，provideguidanceandreferenceforthediagnosisandtreatmentofosteoarthritisMethodsTheaff

4、ectedsidekneejointin24casespatientswithearlyosteoarthritisandin20caseswithadvancedosteoarthritispatientsand20healthyvolunteers’kneejointunderwentmagneticresonancescanning，thepatientsincreasedpressurewith10kgfromplantarlieonamagneticresonancescanfield，acquiredmagneticresonanceimagi

5、ngofthetibiofemoraljointbyFlashseriesofcoronalscan，measuredcartilagecontactlengthineachtomographicimage，accumulatedarticularcartilagecontactareaaccordingtothethicknessoftheslice，andmeasuredcartilagethicknessparameterofstressandnon．stresszoneinthecenterslice．Tookcomparisonbetweenma

6、leandfemaleandcomparingthegroupsResultsThetibiofemoralarticularcartilagecontactareasofmenandwomenofearlyosteoarthritiswere47．50土4．33mm2and41．10士5．901Ill／12，comparedwiththehealthycontrolgroupdecreasedsignificantly(P<0．01)．Theaboveindexincreasedinpatientswithadvancedosteoarthritisan

7、dclosetothenormallevel．Cartilagethicknessofstresszonedecreasedsignificantlyinadvancedosteoarthritistibiofemoraljoint，andcartilagethicknessofnon—stresszoneincreasedsignificantly(P

8、rticularcartilagecontactareaarese