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1、InternationalJournalofWomen’sHealthDovepressopenaccesstoscientificandmedicalresearchOpenAccessFullTextArticleReviewProfileofbevacizumabinthetreatmentofplatinum-resistantovariancancer:currentperspectiveseClairMcClungAbstract:Patientswithplatinum-resistantovariancancerhaveprogressionofdi
2、seasewithinRobertMWenham6monthsofcompletingplatinum-basedchemotherapy.Whileseveralchemotherapeuticoptionsexistforthetreatmentofplatinum-resistantovariancancer,theoverallresponsetoanyoftheseDepartmentofGynecologicOncology,H.LeeMoffittCancerCenter,Tampa,therapiesis~10%,withamedianprogres
3、sion-freesurvivalof3–4monthsandamedianover-FL,USAallsurvivalof9–12months.Bevacizumab(Avastin),ahumanized,monoclonalantivascularendothelialgrowthfactorantibody,hasdemonstratedantitumoractivityintheplatinum-resistantsettingandwasrecentlyapprovedbyUSFoodandDrugAdministrationforcombination
4、therapywithweeklypaclitaxel,pegylatedliposomaldoxorubicin,ortopotecan.Thisreviewsummarizeskeyclinicaltrialsinvestigatingbevacizumabforrecurrent,platinum-resistantovariancancerandprovidesanoverviewofefficacy,safety,andqualityoflifedatarelevantinthissetting.Whilebevacizumabiscurrentlythe
5、moststudiedandclinicallyavailableantiangiogenictherapy,wesummarizerecentstudieshighlightingnovelalternatives,includingvascularendothelialgrowthfactor-trap,tyrosinekinaseinhibitors,andangiopoietininhibitortrebananib,anddiscusstheirapplicationforthetreatmentofplatinum-resistantovariancan
6、cer.Keywords:bevacizumab,angiogenesis,ovariancancer,platinum-resistantovariancancer,recurrentovariancancerIntroductionApproximately225,000newcasesofovariancancerarediagnosedworldwide,and~140,200womendieofthediseaseeachyear.1Whencomparedtoothersolidtumors,ovariancancerhasastrongproclivi
7、tyforearlyperitonealdisseminationandadisproportionatelyhighpercentageofwomenpresentwithadvancedstagedisease.Acombinationofmaximalsurgicalcytoreductionandplatinum–taxane-basedchemo-therapycomprisesthemainstayofprimarytherapy.Approximately75%ofpatientsexperienceaninitialcompleteclinica
