多环芳烃暴露与RAR-β、MGMT基因CpG岛甲基化在宫颈上皮内瘤变中的交互效应

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1、分类号：R183学校代码：10114密级：学号：051510599多环芳烃暴露与RAR-β、MGMT基因CpG岛甲基化在宫颈上皮内瘤变中的交互效应InteractionbetweenPolycyclicAromaticHydrocarbonsExposureandCpGIslandsMethylationofRAR-βandMGMTGenesinCervicalIntraepithelialNeoplasia研究生：王璐指导教师：王金桃教授专业名称：流行病与卫生统计学研究方向：肿瘤流行病学学位类型：科学学位所在学院：公共卫生学院中国山西二〇一八年五月三十日目录摘要..............

2、.................................................................................................................IAbstract.........................................................................................................................IV常用缩写词中英文对照表...........................................

3、..................................................IX前言...............................................................................................................................1材料与方法................................................................................................................

4、.......4结果.............................................................................................................................151.研究对象的人口学特征.............................................................................................152.宫颈上皮内瘤变的相关因素分析.......................................

5、.......................................153.HPV感染与宫颈上皮内瘤变的关系..........................................................................174.PAHs暴露水平与宫颈上皮内瘤变的关系.................................................................185.抑癌基因RAR-β、MGMTCpG岛甲基化与宫颈上皮内瘤变的关系.....................206.PAHs暴露水平与抑癌基因RAR-

6、β、MGMTCpG岛甲基化在宫颈上皮内瘤变中的交互效应.........................................................................................................................217.PAHs暴露水平与抑癌基因RAR-β、MGMTCpG岛甲基化在宫颈上皮内瘤变中的路径分析.......................................................................................................

7、..................22讨论.............................................................................................................................241.影响宫颈上皮内瘤变的相关因素.........................................