阵发房颤患者复律前后血脑钠肽水平及临床意义

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1、第16卷4期天津医科大学学报V01．16．No．46082010年12月JOURNALOFTIANJINMEDICALUNIVERSnYDec．2010阵发房颤患者复律前后血脑钠肽水平及临床意义范耀东，于乃浩，荀丽颖，丁娜，赵连余(天津市第二医院心内科，天津300141)[摘要]日的：观察阵发房颤(AF)患者在复律前后脑钠肽(BNP)水平的变化，探讨BNP在AF发生和复发中的I临床意义。方i支：选择120例心功能正常患者，其中40例为窦性心律对照组，阵发AF患者依据复律结果分复律组35例，复发组35例，失败组lO例；测定对照组以及阵发AF3组复律前后BNP水平和

2、左房内径(LAD)。结摹：(1)阵发AF组LAD和BNP水平明显高于对照组(P<0．01)。(2)在复律前，复律组BNP水平和LAD明显低于复发组和失败组(P<0．叭)；复发组BNP水平和LAD低于失败组，但无统计学意义。(3)复律后2h内，复律组与复发组BNP水平明显下降，均明显低于复律前(P

3、影响因素和预测指标。结论：BNP水平对阵发AF患者预测和评估复律后AF复发有着重要的临床价值。[关键词]脑钠肽；阵发房颤；复律；房颤再发[中图分类号]R541．7[文献标识码]A[文章编号]1006—8147(2010)04-0608-05ChangesofplasmabrainnatriureticpeptideinwithpatientsparoxysmalatrialfibrillationanditsclinicalsignificanceFANYao-dong，YUNai-hao，XUNLi—ying，DINGNa，ZHAOLian-yu(Depart

4、mentofCardiology，TheSecondHospitalofTianjin，Tianjin300141，China)ABSTRACTObjective：Tostudythechangesofplasmabrainnatriureticpeptide(BNP)levelsbeforeandaftercardioversioninparoxysmalatrialfibrillation(ADpatients，andexploretheclinicalsignificanceofBNPinparoxysmalAFpatientsintheoccurrenc

5、eandreccurrence。Methods：120AFpatientswithnormalleftventriclefunctionweredividedintofourgroups：thesinusrhythmgroup／thecontrastgroup(40pa-tients)，thecardioversiongroup(35patients)，therecurrencegroup(35patients)andthefailuregroup(10patients)．Thelatterthreegroupsofpatientswereputtogether

6、accordingtotheresultofcardioversion．PlasmaBNPlevelsandleftatrium(LAD)weremeasuredinallthe120patients，whiletheplasmaBNPlev-elsaftercardioversionweremeasuredinthecardiovemiongroupandtherecurrencegroup．Results：(1)．TheplasmaBNPlevelsandLADofpatientsinthegroupswithAFweresignificantlyhighe

7、rthanthoseinthesinusrhythmgroup(P<0．01)．(2)Beforecardioversion，theplasmaBNPlevelsandLADoftheeardiover-siongroupwereremarkablylowerthanthoseoftherecurrencegroupandofthefailuregroup(P

8、hlittlestati