abca1在子痫前期发病中的作用及其机制研究

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1、分类号：R394.5学校代码：10392学科专业代码：100104学号：200902043福建医科大学博士研究生毕业论文ABCA1在子痫前期发病中的作用及其机制研究TheeffectofABCA1inrelationtopreeclampsiaandtheunderlyingmechanisms学位类型：医学博士所在学院：基础医学院研究生：刘黎星学科、专业：病理学与病理生理学导师：郑鸣教授研究起止日期：2009年9月至2013年3月答辩日期：2013年5月30日二○一三年五月福建医科大学博士学位论文1福建医科大学博士学位论文目录中文摘要·····························

2、·····································································4英文摘要··································································································7正文引言········································································································11第一部分ABCA1基因单核苷酸多态

3、性分布及其与子痫前期患者脂代谢异常的关联研究14材料和方法44························································································15结果··································································································21讨论···········································································

4、·······················28小结··································································································32第二部分子痫前期产妇血清和胎盘组织中ABCA1表达及其与血脂代谢的关联研究33材料和方法························································································33结果·····································

5、·····························································43讨论··································································································52小结··································································································55第三部分正常妊娠与子痫前期血清ABCA1及OX-LDL表达特点及对

6、内皮细胞损伤的影响56材料和方法························································································56中的作用中的作用PI3-Akt信号通路在褪黑素体内外抑制小鼠胃癌细胞增殖中的作结果··································································································62用……………………………讨论·······································

7、···························································70小结··································································································74结论···································