放射性肾损伤中的vwf与卡托普利对其的影响

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1、天津医科大学硕+学位论文increasedat8，16and24weeksafterirradiation(t=3．03-5．13，3．48-4．68，4．68～9．03，P<0．05)，andtherewasanobviouspositivecorrelationbetweencollagenandVWF(r=0．819，P<0．05)；therewasanincreaseinplasmavWFat2，4and16weeksafterirradiation0=3．93-5．03，4．04-5．15，3．48~4．58，P<0．05)，plasmacystatin—C(t=

2、5．10-6．17，P<0．05)andurinaryproteinclearance(t=14．59-16．34，P<0．05)at24weeksafterirradiation，andthepathologicalchangesofkidneyweremildmesangialproliferationat24weeksafterirradimion．Incaptopril+radiationgroup，captoprilfailedtodecreaseplasmavWFattwoweeksafterirradiation(F=I．93，P>O．05)．Exceptfo

3、rthat，captoprilreducedglomerulusvWF(F=15．60，t=9．82，P

4、ilgroup．BloodroutineshowedthatTherewasnoincreaseordecreaseinbloodleucocytes，erythrocytes，hemoglobinandplateletsinradiationalonegroup，controlgroup，andcaptopril+radiationgroupateachpointintimeafterirradiation．ConclusionsTherewasaincreaseinplasmaandglomerularvWF，collagendepositioninglomerular

5、intheearlyradiationrenalinjuryinrats．AndtherewasanobviouspositivecorrelationbetweencollagenandVWFinglonaerular．CaptoprilreducednotonlyplasmaandglomerularVWFbutalsocollagendepositioninglomemlarinradiationrenalinjuryratsandeffectivelyprotectthekidney．ThusweconcludethattheincreasinIrradiatedg

6、lomerularvWFwasmainlyduetothecollagendepositioninglomerular，andendothelialcelldamagemayalsobeinvolved．CaptoprilmightdecreasevWFinglomerularbyreducingcollagendepositioninglomerularandprotectingendothelialcellandreduceplasmavWFbyprotectingendothelialcell．Keywords：RadiationrenalinjuryVonWille

7、brandfactorCollagenCaptoprilIV天津医科大学硕十学位论文目录中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯IAbstract⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯III缩略语／符号说明⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯Ⅵ前言⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1研究现状、成果⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1研究目的、方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯1放射性肾损伤中的