结直肠浸润性微乳头状癌的临床病理学特征及其和淋巴结转移的关系

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1、万方数据天津医科人学硕士学位论文Abstractobjective1．Toinvestigatetheclinicopathologicalfeaturesandimmunohistochemicalphenotypesofcolorectaladenocarcinomawithinvasivemicropapillarycarcinoma(IMPC)component．2．Toinvestigatetherelationshipbetweencolorectaladenocarcinomawithinvasivemieropapillary

2、carcinoma(IMPC)component，lymphovascularinvasion，andlymphnodemetastasis．Methods1．HEstainingandimmunohistochemistrystainingwereusedtoobservetheclinicopathologicalfeaturesandimmunohistochemicalphenotypesin1casesofcolorectaladenocarcinomawithinvasivemicropapillarycarcinoma(IMPC

3、)component．2．131casesofcolorectaladenocarcinomawithinvasivemicropapillarycarcinomacomponentwereevaluatedbyHEstainingandimmunohistochemicalstaining．Themainpathologicalfeatures，percentageofIMPCcomponent，lymphovascularinvasion，andlymphnodemetastasiswereassessed，andcomparedto29

4、6casesofconventionalcolorectaladenocarcinoma．Results1．Inthe1casesofIMPC，6weremalesand5werefemales．Theagerangedfrom26to83years(median61，average59-3)．9tumourslocatedinrectumand2locatedinthejunctionofdescendingandsigmoidcolon．Themaximumdiameterofthetumoursrangedfrom1．5cmto6．5c

5、m．6tu_rnoul'Sshowedulceratingshapeand5tumoursshowedulceratedfungatingshape．Microscopically,allthecarcinomasweremainlycomposedofatypicalcellsarrangedinmicropapillarystructures．5ofthemarepurelyinvasivemicropapillarycarcinoma．Therewerelymphaticinvasionandvenousinvasioninallcas

6、es．Regionallymphnodesrevealedmetastasesinallcases．Duringtheoperation，metastasestotheliverin3cases，peritonealdisseminationin1case，andmetastasestotheleftinguinallymphnodesin1caseweredetected．6monthsafteroperation2patientsdied．8monthsafteroperationIMPCmetastasedtotheuterusinIc

7、aseand4monthslaterthepatientdied．36monthsafteroperationIMPCmetastasedtotheliverin1case．6-38monthsafteroperation4patientssurvivalwithfreetumours．4patientswerelostinfollow·upafteroperation．1lI万方数据天津医科大学硕士学位论文2．ThemaximumdiameterofthetumorsoftheIMPCgroupwassignificantlylowerth

8、antheconventionalgroup．Thedegreeofdifferentiation，thelymphnodemetastaticrate，theav