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1、MolecularPainBioMedCentralResearchOpenAccessNociception-inducedspatialandtemporalplasticityofsynapticconnectionandfunctioninthehippocampalformationofrats:amulti-electrodearrayrecordingXiao-YanZhao†1,Ming-GangLiu†1,Dong-LiangYuan2,YanWang2,YingHe1,Dan-DanWang1,Xue-FengChen2,Fu-KangZhang1,HuaLi1,Xiao-
2、ShengHe*2,3andJunChen*1,2Address:1InstituteforBiomedicalSciencesofPain,CapitalMedicalUniversity,Beijing100069,PRChina,2InstituteforBiomedicalSciencesofPainandInstituteforFunctionalBrainDisorders,TangduHospital,TheFourthMilitaryMedicalUniversity,Xi'an710038,PRChinaand3DepartmentofNeurosurgery,XijingH
3、ospital,TheFourthMilitaryMedicalUniversity,Xi'an710032,PRChinaEmail:Xiao-YanZhao-ibsp01@ccmu.edu.cn;Ming-GangLiu-ibsp01@ccmu.edu.cn;Dong-LiangYuan-brain973@fmmu.edu.cn;YanWang-brain973@fmmu.edu.cn;YingHe-ibsp02@ccmu.edu.cn;Dan-DanWang-ibsp02@ccmu.edu.cn;Xue-FengChen-ifbdlab@fmmu.edu.cn;Fu-KangZhang-
4、zhangfk@ccmu.edu.cn;HuaLi-lihua@ccmu.edu.cn;Xiao-ShengHe*-hexiaos@fmmu.edu.cn;JunChen*-junchen@fmmu.edu.cn*Correspondingauthors†EqualcontributorsPublished:22September2009Received:8September2009Accepted:22September2009MolecularPain2009,5:55doi:10.1186/1744-8069-5-55Thisarticleisavailablefrom:http://w
5、ww.molecularpain.com/content/5/1/55©2009Zhaoetal;licenseeBioMedCentralLtd.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(http://creativecommons.org/licenses/by/2.0),whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisp
6、roperlycited.AbstractBackground:Painisknowntobeprocessedbyacomplexneuralnetwork(neuromatrix)inthebrain.Itishypothesizedthatunderpathologicalstate,persistentorchronicpaincanaffectvarioushigherbrainfunctionsthroughascendingpathways,leadingtoco-morbiditiesormentaldisabilityofpain.However,sofartheinflue
7、ncesofpathologicalpainonthehigherbrainfunctionsarelessclearandthismayhindertheadvancesinpaintherapy.Inthecurrentstudy,westudiedspatiotemporalplasticityofsynapticconnectionandfunctioninthehippocampalfo
