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1、CholinergicPlasticityofOscillatingNeuronalAssembliesinMouseHippocampalSlicesMauraM.Zylla,XiaominZhang,SusanneReichinnek,AndreasDraguhn,MartinBoth*InstituteofPhysiologyandPathophysiology,UniversityHeidelberg,Heidelberg,GermanyAbstractThemammalianhippocampusexpressesseveraltypesofnetworkoscillation
2、swhichentrainneuronsintotransientlystableassemblies.Thesegroupsofco-activeneuronsarebelievedtosupporttheformation,consolidationandrecallofcontext-dependentmemories.Formationofnewassembliesoccursduringtheta-andgamma-oscillationsunderconditionsofhighcholinergicactivity.Memoryconsolidationislinkedto
3、sharpwave-rippleoscillations(SPW-R)duringdecreasedcholinergictone.Wehypothesizedthatincreasedcholinergictonesupportsplasticchangesofassemblieswhilelowcholinergictonefavorstheirstability.CoherentspatiotemporalnetworkpatternsweremeasuredduringSPW-Ractivityinmousehippocampalslices.Wecomparedneuronal
4、activitywithintheoscillatingassembliesbeforeandafteratransientphaseofcarbachol-inducedgammaoscillations.SingleunitsmaintainedtheircouplingtoSPW-Rthroughouttheexperimentandcouldbere-identifiedafterthetransientphaseofgammaoscillations.However,thefrequencyofSPW-R-relatedunitfiringwasenhancedaftermus
5、carinicstimulation.Atthenetworklevel,thesechangesresultedinalteredpatternsofextracellularlyrecordedSPW-Rwaveforms.Incontrast,recordingofongoingSPW-Ractivitywithoutintermittentcholinergicstimulationrevealedremarkablystablerepetitiveactivationofassemblies.Theseresultsshowthatactivationofcholinergic
6、receptorsinducesplasticityatthelevelofoscillatinghippocampalassemblies,inlinewiththedifferentroleofgamma-andSPW-Rnetworkactivityformemoryformationand–consolidation,respectively.Citation:ZyllaMM,ZhangX,ReichinnekS,DraguhnA,BothM(2013)CholinergicPlasticityofOscillatingNeuronalAssembliesinMouseHippo
7、campalSlices.PLoSONE8(11):e80718.doi:10.1371/journal.pone.0080718Editor:GennadyCymbalyuk,GeorgiaStateUniversity,UnitedStatesofAmericaReceivedJuly30,2013;AcceptedOctober16,2013;PublishedNovember18,2013Copyright:ß2013Zyl