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时间:2019-07-02
《Cheng_Oscillatory-bands,-neuronal-synchrony-and-hippocampal-function-Implications-of-the-effects-of-prenatal-choline-supplementation-for-sleep-dependent-memory-consolidation_2008》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、BRAINRESEARCH1237(2008)176–194availableatwww.sciencedirect.comwww.elsevier.com/locate/brainresResearchReportOscillatorybands,neuronalsynchronyandhippocampalfunction:Implicationsoftheeffectsofprenatalcholinesupplementationforsleep-dependentmemoryconsolidationRuey-KuangCheng,Christina
2、L.Williams,WarrenH.Meck⁎DepartmentofPsychologyandNeuroscience,GenomeSciencesResearchBuildingII–3rdFloor,572ResearchDrive–Box91050,DukeUniversity,Durham,NC27708,USAARTICLEINFOABSTRACTArticlehistory:Cholinesupplementationofthematernaldiethaslong-termfacilitativeeffectsonspatialAccepte
3、d22August2008andtemporalmemoryprocessesintheoffspring.TofurtherdelineatetheimpactofearlyAvailableonline9September2008nutritionalstatusonbrainandbehavior,weexaminedeffectsofprenatal-cholineavailabilityonhippocampaloscillatoryfrequencybandsin12month-oldmaleandKeywords:femalerats.Adult
4、offspringoftime-pregnantdamsthatweregivenadeficientlevelofNeuronaloscillationscholine(DEF=0.0g/kg),sufficientcholine(CON=1.1g/kg)orsupplementalcholineGammabands(SUP=3.5g/kg)intheirchowduringembryonicdays(ED)12–17wereimplantedwithanSynchronizationelectroencephalograph(EEG)electrodein
5、thehippocampaldentategyrusincombinationSleepstateswithanelectromyograph(EMG)electrodepatchimplantedinthenuchalmuscle.FivePrenatalcholineavailabilityconsecutive8-hrecordingsessionsrevealeddifferentialpatternsofEEGactivityasaBraindevelopmentfunctionofawake,slow-wavesleep(SWS)andrapid-
6、eyemovement(REM)sleepstatesandNutritionprenatalcholinestatus.ThemainfindingwasthatSUPratsdisplayedincreasedpowerMemoryconsolidationlevelsofgamma(30–100Hz)bandoscillationsduringallphasesofthesleep/wakecycle.CortexThesefindingsarediscussedwithinthecontextofageneralreviewofneuronalHipp
7、ocampusoscillations(e.g.,delta,theta,andgammabands)andsynchronizationacrossmultiplebrainregionsinrelationtosleep-dependentmemoryconsolidationinthehippocampus.©2008ElsevierB.V.Allrightsreserved.1.Introductionrelationshipbetweendietsdeficientinspecificnutrientsandalteredcognitiveoutco
8、meinchildrenandadul
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