心肌缺血再灌注损伤与热休克蛋白

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1、万方数据中国组织工程研究与临床康复第，『蕃算}2，期2007—05～27出版JournalofClinicalRehabilitativeTissueEngineeringResearchMay27,2007V01．71，No．21综述心肌缺血再灌注损伤与热休克蛋白★李顺昌，段意梅，孙涛，苏全生Heatshockproteinandmyocardialischemia／reperfusioninjuryAbstract0BJECTIVE：Hotshockprotein(HSP)asakindofhighlyconservativeproteinisgenerat

2、edfromcellsunderstress．1tcouldprotectcellsthroughresistinginjuryandacceleratingrepair．RecentresearchesshowthatHSPdisplaysthefunctionofendogenousresistancetomyocardialischemia／reperfusioninjury．Inthispaper．wereviewedthemechanismofHSPanditsendogenousresistancetomyocardialischemia／repef

3、fusioninjury．DATASOURCES：Thearticlesabouttheassociationbetweenmyocardiafischemia／reperfusioninjuryandHSPweresearchedmanuallyfromtheIibraryamongtheacademiciournals。especiallythecoreiournalswiththekeywordsof”myocardialinjury，heatshockprotein。ischemia／reperfusion”．Meanwhile，wesearchedCN

4、KIandPubMedforarticlesabouttheprotectionofmvocardialischemia／reperfusioninjurypublishedbetween2004and2006withthekeywordsof”myocardialinjury，heatshockprotein”．STUDYSELECTION：Thirteenandtwenty-ninearticlesabouttheassociationbetweenmyocardialischemia／reperfusioninjuryandHSPwerecollected

5、fromthelibraryandCheInternet，respectively．Inclusivecriteria：Experimentalarticles，namelyprimarydocument．andthosepublishedincoreiournalsorinrecentyears．Exclusivecriteria：Repetitivestudies．DATAEXTRACTION：Totally35articleswerecollected．ofwhich14werepublishedbetween2004and2006，and7between

6、2000and2003．DATASYNTHESIS：HSP，akindofproteinwithhighlyconservativestructure。isgeneratedfromcellsunderstress：itisnearlyfoundinalIlivingbodiesfromprokaryotetoeukaryote．HSPischaracterizedbynon-specificity．highlyconservation，obviouslyHSP．70expressions，timemanner。weakATPaseactivityandcros

7、sresistance．HSPdisplaysaprotectiontocellsinresistinginjuryandacceleraterepair．Peopledidnotpayattentiontotheprotectivee仟ectofHSPonmyocardiumuntiItheendof1980+s．fn1988，CurrieetaItreatedtheSDratSbyHSPpreconditioning．Afieftwenty-fourhoursrest。theratsunderwentmyocardialischemia／reperfusio

8、ninjury．inwh