血府逐瘀汤对大鼠体内药物代谢酶和抗氧化酶的影响研究

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1、学校代码：10600学号：101065学位类型：科学学位广西中医药大学硕士学位论文血府逐瘀汤对大鼠体内药物代谢酶和抗氧化酶的影响研究研究生：樊星花导师：杨秀芬教授院系（部所）：药学院专业：药理学研究方向：生化药理完成日期：2013年5月24日0目录中英文缩略词汇表···············································································1中文摘要························································

2、····································3英文摘要····························································································5引言·····························································································9正文········································

3、···················································10第一部分血府逐瘀汤水提物对大鼠肝脏药物代谢酶活性的影响············101实验材料和方法·············································································101.1实验药物和试剂··········································································101.2实验

4、动物····················································································111.3主要仪器设备··············································································111.4实验方法····················································································111.

5、4.1药物煎煮方法···········································································121.4.2动物给药方法···········································································121.4.3微粒体的制备···········································································121.4.4血府逐瘀汤

6、水提物对正常大鼠肝脏药物代谢酶活性的影响············131.4.4.1氨基比林-N-脱甲基酶(CYP3A)活性的测定································131.4.4.2苯胺-4-羟化酶(CYP2E1)活性的测定··········································131.4.4.3细胞色素b5的测定·································································141.4.4.4NADPH-细胞色素C还

7、原酶的测定·········································141.4.4.5谷胱甘肽-S-转移酶(GST)活性的测定········································141.4.4.6葡萄糖醛酸-转移酶(UDPG-T)活性的测定··································141.4.5统计学处理···············································································1

8、52实验结果·······················································································152