神经调节蛋白1介导星形胶质细胞活化在慢性神经病理性疼痛发生发展中的作用研究

《神经调节蛋白1介导星形胶质细胞活化在慢性神经病理性疼痛发生发展中的作用研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号学号M201075784学校代码10487密级硕士学位论文神经调节蛋白1介导星形胶质细胞活化在慢性神经病理性疼痛发生发展中的作用研究学位申请人：孙娇丽学科专业：麻醉学指导教师：王鹏副教授答辩日期：2013年5月AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofMasterofMedicineTheresearchofneuregulin-1mediatingastrocytesactivationinthedevelopmentofchronicneuropathicpainMa

2、stercandidate:SunJiaoliMajor:AnesthesiologySupervisor:Prof.Dr.WangPengHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2013独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年

3、月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录主要缩略词表····································································

4、······1中文摘要················································································2ABSTRACT············································································6前言····················································································11正文·······························

5、·····················································15第一部分神经调节蛋白1对体外培养的星形胶质细胞增殖和趋化的影响研究·······································································15材料与方法·······································································16结果·························································

6、····················19讨论·············································································24第二部分神经调节蛋白1在神经病理性疼痛大鼠中的作用研究·········27材料与方法·······································································28结果·············································································

7、32讨论·············································································36综述····················································································39综述1······································