硫化氢对急性心肌缺血损伤的影响

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1、河北医科大学学位论文使用授权及知识产权归属承诺本学位论文是在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应的法律责任。研究生签名：每襄花导师签章研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注等内容外，文中不包含其他人已发表或撰写的研究成果，指导教师对此进行了

2、审定。本论文由本人独立撰写，文责自负。研究生签名：诛锐导师签章：碾童纱2名刁弓年尹月≥多日目录中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．1英文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．6英文缩写⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．14研究论文硫化氢对急性心肌缺血损伤的影响引言············．．·····．．············．．．．．．．．．．．．．．．·········．．．．··．．．．．．．15第一部分离体急性缺血心肌内源性硫化氢和胱硫醚吖．裂解酶的变化前言．．．．．．．．．·．．．．．．

3、．．．⋯．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．16刚吾···················”························”··········“···········16材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．16结果············．·．·················．．．·⋯．．·························．．．．19附图············．．．······⋯········．．．·················

4、·················．20附表·．········．．．．．··．．·．······．····．．．·．．．．．····························．25讨论．·········．．．．．·．．．．．····-．·····．．．·．．．．．·························．··．27小结··············．·········⋯·······．···································28参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·28第二部分硫化氢对离体

5、急性缺血损伤大鼠心肌的影响前言⋯⋯⋯．⋯⋯⋯⋯⋯⋯⋯⋯⋯．．．．⋯．⋯．．．．．．．．⋯．．．．．．⋯．．30刖吾““””一．．·一一一“一一一一一”一“一一．．··””一··一．．”一一·一··一30材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯··⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯··．30结果······································································32附图．．·········．．．．···．．·⋯········．．············-·······················33

6、附表⋯···⋯····⋯⋯⋯⋯⋯⋯···⋯⋯····⋯····⋯⋯·············37讨论······································································38／J、结··············”····················一一···一··一·一一···········”···39参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯·39第三部分硫化氢对离体急性缺血损伤大鼠心肌组织氧化应激的影响前言．．．．．．．．．．．．．．．．．．．．．⋯．．．．．．．

7、．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．41日iJ吾·····．．·········””·⋯··”“····“·········”··········”··。一。···一4l材料与方法⋯⋯⋯·OOo⋯⋯⋯⋯⋯．．⋯·QOOI⋯⋯⋯⋯⋯⋯⋯·41结果······································································43附l訇····························································

8、··········45附表．⋯．·．···．．．⋯⋯··⋯⋯···⋯⋯·⋯·⋯⋯····⋯···⋯····