硫化氢对大鼠急性心肌缺血的影响

《硫化氢对大鼠急性心肌缺血的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、1lI目录帅IllLIlIIIIIIIIIlUlIIIlllllllIIIilllltllY1801615中文摘要⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯··1英文摘要DOO⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯OOO⋯⋯⋯⋯⋯··5英文缩写··OOO⋯·OOO⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯OOo⋯⋯⋯··10研究论文硫化氢对大鼠急性心肌缺血的影响引言OODOO······················．．．．．．．．．．．．．·················．·．．·．．．11第一部分急性心肌缺血大鼠内源性硫化氢／胱

2、硫醚一Y一裂解酶体系的变化前言····························．··．．．．．．．．．．．．．··．······．．．．．．．⋯．．．．．．．12刖舌····························································⋯·······12材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．．12结果·OOO················································．．．．．．．15附图······

3、··································．··．-·········-·····．．．．．．．．．．16附表·······························································．．．．．．．22讨论······································．．．．．．···············．．．⋯⋯．．24／J、结····”·······“···········一···．．·．·⋯⋯．．·⋯⋯·⋯·

4、··．．．．一．．．．．．25参考文献⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．25第二部分硫化氢对心肌缺血大鼠线粒体功能及细胞凋亡的影响前言．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．7．．．．．．．．．．．．．．．．．．．．．．．．27日IJ舌·-···········································?························2’7材料与方法⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．-27结果·····

5、·······⋯·-·⋯················．··．·．．··························32附图····················OOO····································．．·····．．．34附表······························．·．．．．．．．．．．．．．··．．．．．．．．．．．．．．．．．．．．．．．42讨论·-·················⋯．．．．．．．．．．．．．．．．．．．．．．．·．

6、．．．．．．．．．．．．．．．．．．．．．．．45／J、结·一·”···”··”·····一一··一·一一．．．．．．．．．一”””．”””“．．．．．．．．．．．47参考文献⋯⋯·⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．47结论·····································．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．49综述内源性硫化氢与心血管疾病的研究进展⋯⋯⋯⋯⋯⋯⋯⋯．．50致谓十··-····························

7、·············．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．61个人简历⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯⋯．62中文摘要硫化氢对大鼠急性心肌缺血的影响摘要心肌缺血是指心脏的血液灌注减少，导致心脏的供氧减少，心肌能量代谢不正常，不能支持心脏正常工作的一种病理状态，严重威胁人类的身心健康，因而对于缺血心肌保护的研究是倍受关注的课题。大量动物实验及临床试验均表明，细胞凋亡是急性心肌缺血损伤发病机制的重要环节之一，线粒体在细胞整合各种凋亡刺激信号的过程中处于枢纽地位。作为继一氧

8、化氮(nitricoxide，NO)和一氧化碳(carbonmonoxide，co)之后的第三种重要化学递质和细胞内信号分子一硫化氢(hydrogensulfide，H2S)一直倍受医学界的关注。内源性H2S主要由半胱氨酸等含硫氨基酸在胱硫醚．13．合成酶(cystathionine．p．synthase，CBS)和胱硫醚．y．裂解酶(cystathionine-丫．1yase，CSE)作用下生成的