涎腺腺样囊性癌中mta1、hif-1α的表达及临床意义

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1、分类号学号M201075880学校代码10487密级硕士学位论文涎腺腺样囊性癌中MTA1、HIF-1α的表达及临床意义学位申请人：王敬学科专业：口腔临床医学指导教师：陶学金教授答辩日期：2013年5月AThesisSubmittedinPartialFulfillmentoftheRequirementsfortheDegreeofMasterofMedicineExpressionofMTA1andHIF-1αinsalivaryadenoidcysticcarcinomaandtheirclinicalsignifican

2、cePostgraduate：WangJingMajor：ClinicalStomatologySupervisor：Prof.TaoXuejinTongjiHospital,TongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030,P,R.ChinaMay,2013独创性声明本人郑重声明，所呈交的学位论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的

3、研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担此声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”

4、）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录英文缩略词表··········································································1中文摘要················································································2Abstract·····························································

5、····················3前言···················································································5实验材料与实验方法·······························································7实验结果············································································11讨论··

6、··············································································16参考文献············································································22综述·················································································27参考文献···············

7、·····························································38致谢·················································································44华中科技大学硕士学位论文英文缩略词表Abbreviations缩写英文全称中文全称SACCSalivaryadenoidcysticcarcinoma涎腺腺样囊性癌MTA1Metastasisassociatedgene1肿瘤转移相关基

8、因HIF-1αHypoxiainduciblefactor-1α缺氧诱导因子1αNuRDNuclearremodelingand核小体重塑与脱乙酰deace-tylationcomplex基复合体HDACsHistonedeacetylases组蛋白去乙酰化酶DAB3,3-d