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大小:379.42 KB
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时间:2019-03-05
《依托咪酯与雷米芬太尼在全身麻醉诱导时的相互作用》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、万方数据!逝压竖醛堂盘查!!!!芏!旦筮!!鲞箜!魍』丛!垒!!!!!!!型!』!!z!!!!!yQ!:!!!型!:!依托咪酯与雷米芬太尼在全身麻醉诱导时的相互作用赵茗妹王国林于泳浩高宝柱·569·.临床研究·【摘要】目的用等辐射分析法研究全身麻醉诱导时依托咪酯、雷米芬太尼之间的相瓦作用。方法择期腹部手术患者75例随机均分为依托咪酯组(E组)、雷米芬太尼组(R组)和复合组(ER组)。各组再分成5个亚组(El~E5,Rl~R、ER-~f■毛组)。麻醉诱导前给药,El~E组分别给予依托咪酯0.040、0.060、0.085、0.1
2、15、0.155nag/kg,R1~RI组分别给予雷米芬太尼5.400、7.105、8.850、11.200、15.540魑/kg,ER-~ER组分别给予依托咪酯及雷米芬太尼0.021mg/kg+2.600馏/kg、0.030rag/kg+3.500馏jkg、0.045rag,/kg+4.200Vg,7Iqg、0.060mg/kg+5.500馏/kg、0.080mg/kg+7.600僻/kg。监测给药前(T1)及给药后lmin(T2)、2rain(T3)、3min(T4)、5min(T5)的SBP、DBP、HR、sp(X、听觉
3、诱发电位指数(AAI)的变化。口令法判断患者是否进入催眠状态。点斜法计算各自药物催眠末点的半数有效量(日兔。,)及复合后两种药物的Ⅱk。以等辐射分析法分析两药在催眠末点的相互作用。结果在催眠末点.依托咪酯E聩r、为0.084nag/k(95%.If,4限0.070~0.103gg/kg);雷米芬太尼Ⅱk为8.i00越/kg(95%可信限7.901~8.435烬/kg);ER组依托咪酯和雷米芬太尼Ⅱ知分别为0.038rng,/kg和3.900旭/kg(95%町信限0.032~0.043t.tg,i'kg和3.760~4.200}
4、lglIkg)。两药在催眠作用£呈现相加。El~E组、R。~№组、ERl~ER组给药前后血流动力学变化无统计学意义。E、ER组T3、T
5、时、B组T2、T3时、ER组T2~T4时AAI显著低于T,时(P6、:A0Mfng-shu,WANGGuo-l7、in,YUYong-hao,eta1.DepartmentofAnesthesiology,GeneralHospital,7ⅥnfinMedicalUniversity,7Ⅵnfin300070,China[Abstract]ObjectiveToinvestigatetheinteractionsbetweenetomidateandremifentanilonthehypnosisusingisobolographicanalysis.MethodsSeventy-fivepatientsscheduledforabdo8、minaloperationswererandomlyassignedintothreegroupsofE。RandER。andeachgroupwasfurtherdividedintofivesubgroupsofE1一E5。Rl—Rj.ERl一ER.Differentdosesofetomidateorremifentanilortheirconbinationswereinjectedbeforeinduction.BP。HR,S·p()2auditoryevokedpotentialsindex(AAl)andcon9、sciousnessatfivetimepointswererecorded.Medianeffectivedose(ED50)wascalculated.IsobolographicanalysiswasperformedtOdiscribetheinteractionsofetomidateandremifentanil.ResultsAtthehypnoticendpoints,theE队。0fetomidatewas0.084mg/kg(95V0C10.070—0.103ktg/kg),EDs。ofremifentan10、ilwas8.100/_£g/kg(95%CI7.901—8.435p-g/7kg)。andE聩oofetomidatewas0.038rag/kgandEDsoOfremifentanilwas3.900g/kg(95%C10.032—0.043“g/kg/3.7604.2
6、:A0Mfng-shu,WANGGuo-l
7、in,YUYong-hao,eta1.DepartmentofAnesthesiology,GeneralHospital,7ⅥnfinMedicalUniversity,7Ⅵnfin300070,China[Abstract]ObjectiveToinvestigatetheinteractionsbetweenetomidateandremifentanilonthehypnosisusingisobolographicanalysis.MethodsSeventy-fivepatientsscheduledforabdo
8、minaloperationswererandomlyassignedintothreegroupsofE。RandER。andeachgroupwasfurtherdividedintofivesubgroupsofE1一E5。Rl—Rj.ERl一ER.Differentdosesofetomidateorremifentanilortheirconbinationswereinjectedbeforeinduction.BP。HR,S·p()2auditoryevokedpotentialsindex(AAl)andcon
9、sciousnessatfivetimepointswererecorded.Medianeffectivedose(ED50)wascalculated.IsobolographicanalysiswasperformedtOdiscribetheinteractionsofetomidateandremifentanil.ResultsAtthehypnoticendpoints,theE队。0fetomidatewas0.084mg/kg(95V0C10.070—0.103ktg/kg),EDs。ofremifentan
10、ilwas8.100/_£g/kg(95%CI7.901—8.435p-g/7kg)。andE聩oofetomidatewas0.038rag/kgandEDsoOfremifentanilwas3.900g/kg(95%C10.032—0.043“g/kg/3.7604.2
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