尿ntx对多发性骨髓瘤骨病变的监测与疗效判断的临床意义

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1、浙江大学硕士学位论文中文摘要的高低与肿瘤的活动程度相关。关键词尿I型胶原交联氨基末端肽(NTx)；多发性骨髓瘤；骨病交；IV浙江大学硕士学位论文英文摘要ClinicalSignificanceofurinaryN-telopeptideoftypeIcollagenontreatmentofboneabnormalitiesinmultiplemyelomaBackgroundCollegeofMedicine，ZhejiangUniversityCandidate：LuJinSupervisor：Prof．ZhenCaiAbstractMultiplemyelom

2、a(MM)isaneoplasticplasma-celldisordercharacterizedbyosteolyticbonediseaseresultinginskeletal-relatedevents(SRE)，whichnotonlyresultinanegativeimpactonpatients。qualityoflife，butalsoincreaseeconomicburden．About2／3ofthepatientsexperienceseverepain，and80％ofthemshowskeletalabnormalitiesinx—r

3、ay,includingpathologicfractures，diffuseosteoporosisandosteolyses．Manypatientshadbeentreated、衍tllbisphosphonateduringchemotherapy．Now,diagnosisandmonitoringofbonediseasemainlydependonimaging，butlowsensitivityofthex-ray,andhighexpensesofPositronemissiontomography-computedtomography(PET-C

4、T)，Magneticresonanceimaging(MRl)，CTlimitedtheiruse．Theclinicaldetectionsofserumaikaiinephosphatase(AKP)reflectingserumosteoblastactivityandcalciumconcentrationreflectingthebalancebetweenmineralizationandboneresorptionareconvenient，butnotspecific．Newlaboratoryparametersthatreflectboneme

5、tabolismaccuratelyareurgentlyneeded．Inrecentyears，ithasbeenfoundthattypeIcollgencross·linkedN-telopeptide(NTx)playsallimportantroleforbonelesiondetectioninmanydiseasesbutseldomreportedinMM．V浙江大学硕士学位论文英文摘要MethodsIntlusstudy,patients、析mMMwerediagnosedbetween2009anddecember2010including64

6、patients、析tllmultiplemyelomareceivedbisphosphonateandchemotherapytotreatbonepain．WedetectedthelevelofurinaryNTx／Crofthe64patientsbyELISAtechniquesbeforeandafterthreemonthsoftreatment，aswellas-(川KP)，serulTlcalcium，GLB，p2-MGCr,Hb．Resuits(1)TheurinaryNTx／CrofpatientsinD—SstageIIIWashigher

7、thanthatofpatientsinstageI，II；thelevelofurinaryNTx／Crdecreasedsignificantlyafterchemotherapy，thereWasstatisticalsignificance；andwiththeprolongedtheperiod，urinaryNTx／Crdecreased；andthepatientsofmildreactionornoreactionaftertreatmenthadhigherlevelsofurineNTx／Cr．Atthesametime，wealsofoun