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ID:34130726
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时间:2019-03-03
《葡多酚对早期糖尿病肾病患者血浆内皮素的影响和意义》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、参考文献葡多酚对早期糖尿病肾病患者血浆内皮素的影响和意义张新安钟进义(青岛大学医学院医学营养研究所,青岛266021)【摘要】目的探讨葡多酚(GPC)对早期糖尿病肾病患者血浆内皮素-1(ET-1)和24小时尿白蛋白排泄率(UAER)等的影响及临床意义。方法将38名早期糖尿病肾病患者随机分为实验组(n=19)和对照组(n=19)。对照组采用糖尿病常规治疗,实验组在常规治疗基础上加用葡多酚治疗,每天一次200mg口服,两组疗程均为8周。另选择20名正常人为健康组。采用放射免疫法分别测定对照组和实验组治疗前后血浆ET-1和24h尿白蛋白排泄率(UAE
2、R),测定健康组查体时的血浆ET-1。结果早期糖尿病肾病实验组和对照组治疗前血浆ET-1均较健康人组血浆ET-1显著升高(p﹤0.01),早期糖尿病肾病患者治疗前血浆丙二醛水平与UAER呈显著正相关。早期糖尿病肾病实验组治疗8周后血浆ET-1(68±4.24ng/L)较治疗前血浆ET-1(115.8±15.5ng/L)显著下降(p﹤0.01),对照组治疗后血浆ET-1(106±10.7ng/L)较治疗前血浆ET-1(114±0.9ng/L)下降不明显(p>0.05),实验组治疗后UAER(70.51±32.17ug/min)较治疗前UAER(1
3、12.42±69.11ug/min)明显下降(p﹤0.01),对照组治疗后UAER(98.30±45.84ug/min)较治疗前UAER(103.15±69.14ug/min)下降不明显(p>0.05)实验组血浆ET-1降低与UAER降低呈显著正相关(p﹤0.01)。结论糖尿病肾病(DN)的发生与血浆内皮素-1水平升高有关,提示了血管内皮损伤参与DN的发生发展。葡多酚明显降低糖尿病肾病(DN)血浆中内皮素-1含量,具有维持血管内皮细胞功能,对DN的肾脏功能起到一定改善和保护作用,为GPC治疗DN提供了理论依据。关键词:葡多酚;糖尿病肾病;内皮素
4、-1;24小时尿白蛋白排泄率EffectandClinicalSignificanceofGrapeProcyanidinsonEndothelin-1inPatientswithearlyStagediabeticnephropathy[Abstract]Objective:TostudytheEffectandClinicalSignificanceofGrapeProcyanidinsonEndothelin-1andUAERinPatientswithearlyStagediabeticnephropathyMethods:Random
5、divisonof38casesofearlydiabeticnephropathyintothecontrastinggroupandtheexpermentalgroup.Thecontrastinggroupwasapplieddiatetienephropathy(DN)regulartreatmentandtheexperpentalgroupwasaddedtoGrapeProcyanidinscapsuleonthebasisofregulartreatmentonetimeperdayandbeing参考文献taken0.2ge
6、verytime.Bothofthemwouldbetreated8weeks.Therewasanothergroupmadeof20healthypeople.obtainingthechangesofUAERandET-1,anddifferentgroupthroughradioimmunoussaymethod.Results:ThelevelofplasmaET-1takenfromtheDNpatient,washigherthanthehealth.ThelevelofplasmaET-1,takenfromtheexperme
7、ntalgroupwasobviouslydeclinedafterhavingbeentreated(P‹0.01).ThelevelofplasmaET-1takenfromthecoatrastinggrouphadnodistinelchangeafterhavingbeentreated(P›0.05).ThelevelofplasmaET-1andUAERtakenfromtheexpermentalgroup,wasobviouslydeclinedcomparewiththecontrastinggroupaftertaking
8、treatof8weeks(P‹0.01,P‹0.01).ThedeclineofplasmaET-1wasobviouslyparalleltode
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