合并卵圆孔未闭的脑白质病变与多发性硬化的临床与影像对比分析

《合并卵圆孔未闭的脑白质病变与多发性硬化的临床与影像对比分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、Abstractobjective：ToinvestigatetheclinicalandimagingcharacteristicsofPFO—relatedWMLsandcomparewithmultiplesclerosis(MS)．MaterialsandMethods：RetrospectivelyreviewthepatientswithPFO-relatedWMLsandMSfollowedfrominpatientdepartmentofneurologyofChinesePLAGeneralHospitalduringAu

2、gust2009andAugust2012．Theclinicalcharacteristicswerecomparedbetweenthetwogroups．Results：Atotalof31PFO—relatedWMLspatientsand91MSpatientswereenrolled．111eratiosofmaletofemaleofthePFO-relatedWMLsandMSpatientswere1：0．93and1：2．5．andtheaverageagesofonsetwererespectively41．58±12

3、．31and32．56±13．39yearsold．InPFO—relatedWMLspatients．thetraditionalriskfactorsofcerebralischemicdiseasearerelativelyfew,buttheproportionofpatientswithhistoryofheadacheandcardiacexcrescenceisrelativelyhi曲(22．6％and25．9％、．ThesymptomsofcerebrumdamageespeciallyheadacheinPFO-rela

4、tedWMLspatientsaresignificantlymorethanMSpatients衅0．05)，however,theoppositeresultsareinthesymptomsofbrainstemandspinalcorddamagebetweenthetwogroups．LesionsaresignificantlymoredetectedindeepwhitematterinPFO—relatedWMLspatients(77-4％VS54．9％)，andlessinthecorpuscallosum(3．2％VS

5、26．3％)andinfratenrorialareas(5．7％VS49．5％)(P<0．05)．LesionsinPFO—relatedWMLspatientsaremorelikelytobesmall，mottlingandunenhancedchangesonMRI．Ontheopposite，lesionsinMSpatientsaremorelikelytobelarger,lessclearedgedandpatchingorellipseshapedchangeswhichCanbeenhancedinvarietyofs

6、hapesduringtheacutephase．111eresultsofVEPandCSFexaminationinPFO—related、7lMLspatientsarenormal．butmostofMSpatientshavepositiveresults，includingabnormalVEP(74．1％)，andelevatedprotein(39．06％)，elevatedIgG(50％)，andpositiveoligoclonalzone(72．72％)inCSEConclusion：ComparewithMS，PFO

7、·relatedWMLsaremorelikelytoaffectmiddle—agedpeople，andtheincidenceshowsnostaticallydifferencebetweenmaleIIIAbstractandfemale．Thesymptomsofcerebrumdamagearemorecommon，especiallyhe．acheanddizziness．Significantly,lesionsaremoredetectedindeepwhitematterinPFO-relatedWMLspatient

8、swhilelessincorpuscallosumandinfratenrorialareasthanMSpatients．LesionsinPFO-relatedWMLspa