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1、丁爱侠：几种药物对日本蟳的毒性毒理研究muchmoresensitivethanmuscleandheart.ItprovidedthebiochemicalevidencethatthemechanismoftoxicitywascloselyrelatedtothenutritionmetabolismindigestiveandrespiratorysystemofCharybdisjaponica.Isozymewasconsideredtobeasauxiliarybiochemicaldiagnosismarkerintheearlystageofthewa
2、terpollution.InChapter4,effectsof4chemicals(0.5mg/LCuSO4·5H2O,30mg/Lchoramphenicol,0.27mg/Ltriazopniosand0.6mg/Lbleachingpowder)onultrastructureofcellin4tissues(heart,gill,muscleandhepatopancreas)ofCharybdisjaponicawasstudied.Theresultsshowedthatthemainalterationinmusculatureandmyocardia
3、lcellwerebothmitochondriaandmyofibril.Mitochondriashowedswellingandalotofvacuolus,andmyofibrilbrokeandlosedcontractedfunctionofmyocardiumwithirregulailightanddarkbands.Besides,swollennuclearmembraneanddecreasedendoplasmicreticulumwerealsofoundinthosecells.Thegillcellstreatedwith4chemical
4、shadanobviousultrastructuralvariation.Theparallelandorderedstructureofmusclewasdestroyed,andendoplasmicreticulumwasswollenup,dilatedandvesiculated.Cristaesinmitochondriawasswollenup,anddisintegratedpartially.Cuticleofgillfibrewasdenaturedanddropped,andnuclearmembranewasswollenupandpartia
5、llydissolved.Theultrastructuraldamagestohepatopancreaticcellweremainlydecreasedmicrovilli,mitochondria,increasedlipiddroplets,decreasedendoplasmicreticulumanddisruptionandvacuolizationofnucleusandnuclearmembrane.Changesingillandhepatopancreasweremuchmorethanthoseofthetwoinheartandmuscle.
6、Theeffector4chemicalsfromhightolowcouldbeorderedas:triazopnios>coppersulfate>bleachingpowder>chloramphenicol.Chapter5istoapproachthedetoxifymechanismandfindoutdetoxifymethods.KeywordsCharybdisjaponica,choramphenicol,triazopnios,coppersulfate,bleachingpowder,toxicity,toxicology,toxictest,
7、protectiveisozyme,isozyme,ultrastructure,detoxifymechanism,detoxifymethodsv丁爱侠：几种药物对日本蟳的毒性毒理研究第一部分前言一选题意义中国的经济发展正在创造奇迹，但同时也面临着人口膨胀、资源短缺和生态环境恶化的沉重压力和严峻挑战。宁波是一个经济发展迅猛、生活环境舒适的沿海城市，在2004年全国城市综合评比中更是挤进了前十位。宁波依靠东海的天然港口优势和丰富的海洋资源大力发展海洋运输和海洋渔业，带动了其他经济形式的发展，但是，同全国其他沿海城市一样也面临着海洋环境污
