活血补肾综合疗法治疗慢性盆腔炎疗效评价及调控模型大鼠血管内皮细胞功能、抗粘连机制的研究

《活血补肾综合疗法治疗慢性盆腔炎疗效评价及调控模型大鼠血管内皮细胞功能、抗粘连机制的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、MMP-2的表达优于其他治疗组。结论：活血补肾综合疗法治疗本病安全有效，值得临床推广使用。通过对慢性盆腔炎模型大鼠血管内皮细胞因子、抗粘连相关指标的调控，使机体血管扩张，改善循环状态，增加盆腔有效循环血流量，从而改善了盆腔缺血缺氧的瘀血状况，促进炎症的吸收以及萎缩腺体的恢复，松解盆腔粘连。关键词慢性盆腔炎；活血补肾法；综合疗法；血管内皮细胞功能；抗粘连1TheClinicEffectEvaluationofActivatingBloodandTonifyingtheKidneyonComprehensiveTreatingChronicPelvicInf

2、lammatoryDiseaseandExperimentalStudyonTheEffectsonEndothelialFunctionandAntiadhesionoftheExperimentalModelRatsSpeciality：GynecologyofTCMAuthor：YuYuan-yuanTutor：Pro.LiuRui-fenAbstractObjective：Toevaluatethecliniceffectofchronicpelvicinflammatorydisease(CPID)ofbloodstagnateanddefic

3、iencyofthekidneytreatedbycomprehensivetreatmen,andprovidingevidencesforclinicalscientificapplication.Toexplorethemechanismofthetreatmentofpromotingbloodcirculationandtonifyingthekidneycomprehensivetreatmentontheratswithchronicpelvicinflammatorydisease（CPID）byobservingthechangesof

4、endothelialfunctionandantiadhesion.Methods：Thesubjectusedrandomized，multi-center，blindedevaluationoftestmethod,162casesofchronicpelvicinflammatorydiseaseofbloodstagnateanddeficiencyofthekidneyweredividedintotwogroupsrandomly;treatmentgrouphad79casesthatisPENQIANGYANRecipe+PENYANX

5、IAOenema+dregsextemalapplicationtherapy;controlgrouphad83casesthatisPENQIANGYANRecipe.Observeclinicalefficiency,TraditionalChinesemedicinesymptoms，physicalsignsandqualityoflifeafterthetreatment.FemaleWistarratswereusedandtheCPIDmodelwasestablishedwithsleepingdeprived+ringterrifie

6、d+mixedbacteriainjection+mechanicinjury.Seventy-tworatswererandomlydividedintonormalgroup，shamoperationgroup，modelgroup，takingherbsorallylarge，mediumandsmalldosegroupsandcomprehensivetreatmentlarge，mediumandsmalldosegroup.Thehistomorphologicalchangesoftherats'uteriwereobservedusi

7、nglightmicroscope.Theenzyme-linkedimmunosorbentassay(ELISA)wasappliedtomeasuretheconcentrationofEndolhelin-l(ET-1)、ThrombusB2(TXB2)and6-ketone-proststeF1(6-keto-PGF1)inserumofratsineachgroup.TheimmunochemistrymethodwasusedtodetecttheexpressionofInsulin-likegrowthfactor-1(IGF-1)

8、、Fibroblastgrowthfactor-2(FGF-2)andMatri