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1、重庆医科大学硕士研究生学位论文ACUTEISCHEMICSTROKEASSOCIATEDPNEUMONIARISKFACTORSANDINFLUENCEONPROGNOSISABSTRACTObjectiveThepurposeofthisstudywastodiscusstheriskfactorsforstroke-associatedpneumonia（SAP）andprognosisonacuteischemicstrokepatientsforprovidingthebasisofclinicalprevent
2、ionandtreatment.MethodsAcase-controlstudywasconductedin144hospitalizedpatientswithacuteischemicstrokeadmittedinthedepartmentofneurologygeneralwardoftheSecondAffiliatedHospitalofChongqingMedicalUniversitybetweenJanuary,2013andJanuary,2015.Accordingtodiagnosticcrit
3、eria,thepatientsweredividedintoSAPandnon-SAPgroup.Medicalrecorddata(age,gender,smokinghistory,historyofhypertension,diabetes,heartdisease,atrialfibrillation,oldcerebralinfarction,chronicobstructivepulmonarydisease),clinicalfeature(temperature，bloodpressure,dyspha
4、gia,pulmonaryphysicalexamination),laboratorydata(fastingblood-glucose,glycolsylatedhemoglobin,lowdensitylipoproteincholesterol,whitebloodcellcount,albumin),imagingfindings(chestX-rayorCTfindings,strokelocationandvolumeoncranialCTorMRI,whethercombinewithleukoaraio
5、sisandseverity),diseaseseverity4万方数据重庆医科大学硕士研究生学位论文assessmentandprognosisevaluation(durationofhospitalization,NIHSSscoreandmodifiedRankinscaleatadmissionanddischarge,whetherdeathinhospital)werecollected.SinglefactorandmultiplefactorsLogisticregressionanalysisther
6、elatedriskfactorsofSAPandinfluenceonprognosis.Results46diagnosedwithSAPin144patientsofacuteischemicstroke.Singlefactoranalysisshowedthatrateofage≥70years,hypertension,heartdisease,atrialfibrillation,chronicobstructivepulmonarydisease,oldcerebralinfarction,disturb
7、anceofconsciousness,dysphagia,whitebloodcellcount,diastolicbloodpressure,NIHSSscoreandmodifiedRankinscaleatadmission,strokelocation(especiallyinsular)andvolume,leukoaraiosisinSAPgroupweresignificantlyhigherthanthoseinnon-SAPgroup(P＜0.05).Inmultiplyfactorsregressi
8、onanalysisshowedthatinsularstrokeanddysphagiawereindependentriskfactors.InsularstrokeOR=5.64，95%CI[1.41-22.64],P=0.015，dysphagiaOR=11.48,95%CI[2.54-5.97]，P=0.0
