大鼠骨质疏松模型的建立和放射状体外冲击波对大鼠骨质疏松模型的干预的相关分析

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1、英文摘要TheOsteogenicExertsOfRadialExtracorporealShockWaveOnOsteoporoticInAnOvariectomizedRatModelABSTRACTOsteoporosis(OP)，amajorpublichealthproblem，isachromcskeletaldiseasecharacterizedbylowbonemineraldensityresultinginIragilebones一‘●一--●withincreasedriskoffracture．Thefracturesandthesubsequentmorbidi

2、tyandmortalitycausedbyOPasenormouspublichealthconcern．Pharmaceuticalapproachesneedregularintakeofmedicationandhavepotentialadversesideeffects．Exerciseprogramsandbiophysicalinterventions，asthealtemativetreatments，arethemostcommonandeffectivestrategiesfordecreasingtheriskofdevelopingosteoporosis．Sho

3、ckwavesareacousticalpulsesthatarecharacterizedbyahighpeakpressurerangingfrom5to130Mpa，withamostcommonenergyof50Mpaandabroadfrequencyof14Hzto20MHz，themostsignificantaspectofthisformofenergyisrapidinitialriseinpressureamplitudeoverashorttime1essthan10ns．Extracorporealshockwavesareknowntostimilatethe

4、differentiationofmesenchymalstemcellstowardosteoprogenitorsandinducetheexpressionofosteogenic—relatedgrowthproteins．Extracorporealshockwavetherapy(ESWr)iseffectiveinthetreatmentofnonumonsandfractures．ESWisanonsurgicaltreatmentandaccompaniedbylesspotentialadversesideeffectsthanPharmaceuticalapproac

5、hes．Inthiss西“radialextracorporealshockwavewasappliedtotheosteoporosisratsmodel．Weinvestigateifradialextracorporealshockwaveaffectednewboneformationandbonemicroarchitecture．Part1EstablishmentofratosteoporosismodelbyovarieetomyObjective：Toinvestigatethefeasibilityofestablishratsoteoporosismodelbyova

6、riectomyplusMethylprednisolone画ection．Methods：Twenty．．four24．week-oldfemaleSDratsw&edividedintothreegroupsrandomly．GroupA，eightratswerebilaterallyovariectomized；————————————————————————————————————————————————————————一4英文摘要GroupB，shameoperation(non-osteoporotic)；GroupC，eightratswerebilaterallyovar

7、iectomizedandplusMethylprednisoloneinjection．Beforeoperationand2monthsafteroperation，theBMDweremeasuredbydouble·energy—X-rayabsorptionmeter．2monthsafteroperation，theanimalswerekilledwithuseofanoverdoseofpentobarb