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ID:36640337
大小:2.22 MB
页数:35页
时间:2019-05-13
《骨碎补对去卵巢大鼠骨质疏松模型的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、山西医科大学硕士学位论文骨碎补对去卵巢大鼠骨质疏松模型的影响姓名:李凤芝申请学位级别:硕士专业:中西医结合妇科指导教师:张永洛2003.5.30山西医科大学硕士学位论文骨碎补对去卵巢大鼠骨质疏松模型的影响研究生李凤芝导师张永洛教授内容提要目的:探讨骨碎补防治骨质疏松症的作用机理。方法:将40只3月龄雌性Wistar大鼠随机分为正常对照组(假手术组)、模型组、尼尔雌醇组、骨碎补水提组、骨碎补醇提组。去卵巢术后l周开始给药,喂养12周后对各组大鼠骨密度、体重的改变进行比较,采用放射免疫分析方法对各组大鼠血清雌二醇(Ez)、骨
2、钙素(BGP)的水平进行比较并观察骨、子宫组织形态学变化。结果:模型组与正常对照组大鼠比较体重显著增加(PO.05)。模型组与正常对照组、骨碎补水提组及醇提组BMD比较,有显著性差异(PO.05)。模型组大鼠血E。水平明显低于正常对照组、骨碎补水提、醇
3、提组,差异有显著性(P4、etherapeuticeffectsandmechanismofdrynariaonosteoporoticovariectomized(OVX)ratsmodels.Methods40Wistarfemaleratsabout3monthswererandomlydividedinto5groups,8ineach:normalgroup(shamedoperationsgroup),ovariectomizedgroup,nilestriolgroup,waterpharmaceuticalpreparationo5、fdrynariagroup,ethanolpharmaceuticalpreparationofdrynariagroup.After1weekofoperation,thedrugswereinitiatedseparatelyoneachrat,12weekslater,bonemineraldensity(BMD)wasmeasuredbydual-energyXrayabsorptiometryandtheweightWaScompared.moreover,RadioimmunoassayWaSusedtoa6、nalysebloodlevelofestradiol(Ez),osteocalcin(BGP)ofeverygroup,andhistomorphologicalfeaturesofboneanduterusoftheratswerealsoobserved.ResultstheweightwasincreasedsignificantlyinOVXratsascomparedwithnormalgroup(P<0.05).AscomparedwiththeOVXgroup,theweightinthenilestri7、olgroup,waterpharmaceuticalpreparationofdrynariagroup,ethanolpharmaceuticalpreparationofdrynariagroupWeredecreased(P8、onofdrynariagroup(P
4、etherapeuticeffectsandmechanismofdrynariaonosteoporoticovariectomized(OVX)ratsmodels.Methods40Wistarfemaleratsabout3monthswererandomlydividedinto5groups,8ineach:normalgroup(shamedoperationsgroup),ovariectomizedgroup,nilestriolgroup,waterpharmaceuticalpreparationo
5、fdrynariagroup,ethanolpharmaceuticalpreparationofdrynariagroup.After1weekofoperation,thedrugswereinitiatedseparatelyoneachrat,12weekslater,bonemineraldensity(BMD)wasmeasuredbydual-energyXrayabsorptiometryandtheweightWaScompared.moreover,RadioimmunoassayWaSusedtoa
6、nalysebloodlevelofestradiol(Ez),osteocalcin(BGP)ofeverygroup,andhistomorphologicalfeaturesofboneanduterusoftheratswerealsoobserved.ResultstheweightwasincreasedsignificantlyinOVXratsascomparedwithnormalgroup(P<0.05).AscomparedwiththeOVXgroup,theweightinthenilestri
7、olgroup,waterpharmaceuticalpreparationofdrynariagroup,ethanolpharmaceuticalpreparationofdrynariagroupWeredecreased(P8、onofdrynariagroup(P
8、onofdrynariagroup(P
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