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1、-第四军医大学硕士学位论文StudyonestablishmentofrabbitosteoporosismodelandthefeasibilityofextracorporealshockwavetherapyonosteoporosislocalbonetissueCandidateformaster:ZhangKunSupervisor:LiuJianDepartmentoforthopaedics,Xijinghospital,FourthMilitaryMedicalUniversity,Xi’an710032,ChinaAbstractOsteop
2、orosisfractureisadiseasethatmostthreatenthelifeofagedpeoplenow.Thecharacteristicofosteoporosisincludebonestrengthdegraded,microarchitecturebrokenandfragilityincreasedwhichlendtheosteoporosisfracturehappenedmoreeasily.Oncefracturehappens,itisverydifficulttobetreated,andthetherapeutice
3、fficaciesarenotsatisfactorywhichmaybadlyaffectspatients’life,inducedpatientsdisabled，evendied.Therefore,preventandtherapyinosteoporosisarehighlyimportant.Nowadays,fortheosteoporosis,medicaltherapyistheprimarymeasure.Butthemedicaltherapyhavesomeofinsufficiency,suchastakelongtime,untow
4、ardeffectsevidently,therapeuticefficaciesareslowly,soitismoredifficulttoincreasethebonedensityandstrength.Extracorporealshockwavetreatmenthavemoreeffectintreatmentoffractureandnonunionthattestifiedbystudies,especiallyintheprocessofboneformation.However,osteoporosisaredisplayedbonesor
5、ptionenhancementandboneformationweaken.Forthisreason,inthisstudyextracorporealshockwavewereappliedtotheosteoporosisanimalbonetissue,accordingtothebone-5-------第四军医大学硕士学位论文formationeffectofextracorporealshockwave,toinvestigateitwouldwhetherinfluencedtheprocessofcancellousbonerebuild,i
6、ncreasedbonedensityandimprovedbonequalityornot.Part1:EstablishmentofRabbitOsteoporosisModelbyOvariectomyplusDexamethasoneIntramuscularInjectionObjectiveToinvestigatethefeasibilityofestablishrabbitosteoporosismodelbyovariectomyplusDexamethasoneintramuscularinjection.Methods24fivemonth
7、soldfemaleNewZealandwhiterabbitsweredividedintothreegroupsequally.GroupA,shameoperationplusSodiumChlorideintramuscularinjection.GroupB,ovariectomyplusSodiumChlorideintramuscularinjection.GroupC,ovariectomyplusDexamethasoneintramuscularinjection.Thebilateralovariesofthelasttwogroupswe
8、reectomized.
