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ID:33786882
大小:4.24 MB
页数:38页
时间:2019-03-01
《hifu热消融过程中空化与温升、凝固性坏死的关系》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、THEREIATIONSHIPBETWEENCAVITATIONANDTEM呼ERATURERISE、COAGUIATIONNECROSISDURINGHIGHINTENSrrYFOCUSEDUIJRSOUNDINDUCEDTHERmLABLATIONPROCESSBACKGROUNDABSTRACTHighintensityfocusedul仃as咖1dtumormer印y,:aprecisefocusonnon。mVaslvetumors仃eatmentwimnosl(iniIlcision,hasa
2、goodemcacyandsaf.e哆andshowsgoodprospects.TheHIFUresulⅡngi11tissuethennalcoagulationnecrosisisaVe巧compleXtraIlsientprocess.Tllep血cipleistomakeuseofmeul仃asoundbe锄whichhasconve略encecharact舐stics,aIldpene仃atiIlginmeo略砌zationa11dmeiIlllerentsoulldabso印tionchal
3、_actens廿cs.Theultrasoundwillbel眦lchedinvi仃oul仃asollicfbcusingtopromotetargettissuetoasmallre百onofbody.Withmememale彘cts,caV油tionandmechaIlicale舵cts,itproduce订ansienthi曲temperatureaboVe60℃,aJldthustllefomationofirreversiblecoagulationnecrosisinordertoachieV
4、ethepu印oseoftreatInent.Basedontheresultsoft11en】1aldoseresearch,ithastoreachacertailltemperatureandlastforsometimeinHIFU仃e锄entprocesstoproducecoagula廿onnecrosis.Tllerefore,real-timetemperaturemonito咖gintarget6re百onhas伊eatsi嘶ficallceone街cacyevaluationandⅡl
5、erapydosedeten】1ination.HIFUdestmctionmechallismintargettissueismailllVme胁ale疏ctaIldcaVitatione虢ct.Heatisconvened舶mul仃asoundabso印tioninta唱et缸ssue.Whenul仃asoulldi11radiateswimthesoundpressureexceedillgacenain心eshold,tinyaircoreorcavitiesexpallds锄dfIomscaVi
6、tationbubbles.CaVitationist11eselIiesofdynaIIlicsofcavitationbubblesuIldersoundpressure,suchasoscillation,铲owth,contractionauldcollapse.StudieshaVeshownthats旬rongcavitationactivit_ywillleadtohi曲teInperature,11i曲pressure,shoCkwave,m曲.speedjetaIldsuchphysic
7、alphenomena,aJlofwhicharelikelytoimpactthethermale虢ctaJldcoagula石onnecrosisfomation.Themlocoupletemperaturemeasur锄entandpassivecavitadondetectionisusedtomonitorta玛etregion’st锄peratureelevationandcaVitationchallgesoVertimeiIlmeHIFUirradiationinVi仃obovineli
8、ver.toeXploremerelationsllipbetweencavitationa11dt锄peraturerise.Recordsofcoagulationnecrosisfo衄ationinbovineeyelens址enbvHi曲。speedphotography,combinedwithcaVitationsi印alaIlalysis,areusedtoaIlalyzetherelationshipbe铆ee
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