生物材料人工胸壁重建犬胸壁骨性缺损的动物实验分析

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1、中山大学硕士学位论文生物材料人工胸壁重建犬胸壁骨性缺损的动物实验研究TheanimalstudyofbonyChestwallreconstructionwithbio-materialartificialchestwallindogsMajor：OncologyName：Wu—pingWangSupervisor：ProfLanjunZhangAbstractBackgroundChesttumor、trauma、infection、radiationinjuryandabnormalityarethecommoncausesofchestwalldefect

2、s．Forlargedefectoranterlateralchestwalldefects，theparadoxicalbreathingoftenhappens，whichmaycausetherespiratoryorcirculationfailure．Toavoidthis，chestwallreconstructionmustbeperformedatpresents．Ingeneral，thechestwallreconstructionincludesthemanagementofpleuracavity、chestskeletalsupport

3、andsofttissuecoverage．whilethechestskeletalsupportmayplaymoleimportantroleinsustainingchestwallintegralityandstablity,itsprocessissocomplexthatdifferentnature-deriviedorsyntheticmaterialmustbeusedtorepairit．Atpresent，the“Sandwish'’methodwasconsideredasasimpleandeffectivewaytoberecomm

4、ended．However,italsohavesomeshortcomings，forexample，thebonecementhinderschestwallmovement；Thehighmoleculepatchorbonecementcalla’tbeusedincasesofinfection；thebonecementisradiopaque，whichhavebadeffectonthepostoperativeradiotherapyorX-rayexamination．So，moreresearchalestillneededinsearch

5、ingforabetterreconstructionmethod．Inourstudy,wefirstestablishedthehugechestwalldefectmodelinchinesedogs，thenwerepairthechestwalldefectbyusinganewbiomaterialartificialchestwallbuildwimporcine-derivedartificialribandpleura．bycomparsionwith“sandwish'’V中山大学硕士学位论文生物材料人工胸壁重建犬胸壁骨性缺损的动物实验研究m

6、ethod，wediscussthesafetyandefficiencyofthisnewreconstructionmethod．MateriaIsandMethods1．Bonychestwalldefectmodel：TwelvemaleandfemaleChinesedogsweighingl5-20kgwereobtainedfromtheGuangdongExperimentalAnimalCenter．AfterGeneralanesthesiaandendotrachealintubationforbreathing,astandardpost

7、erolateral8·10cmincisionwascreatedtoexposethefifthtoeighthribsandintercostalmuscles．An8×7cmzbonychestwalldefectmodelWasestablishedafterenblocresectionofthreeribs，theintercostalmuscles，andparietalpleura．2．Biomaterialartificialribandpleura(Experimentgroup)．3．“Sandwish"complexmaterial(C

8、ontrolgroup)