kupffer细胞表达的fas配体在急性胰腺炎肝损伤中的作用

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1、硕士学位论炙hepaticinflammationandinjurywhichappearedidenticaltothatseenduringAP．Preventionofinflammatorymediatorproductionbyintrahepaticleukocytesattenuatesinjury．IthadalsodemonstratedthatpancreaticelastaseinducedliverinjurybyactivatingcytokineproductionwithinKup

2、ffercellsviaNF-rc8，gadoliniumexhibitedaprotectiveeffectagainstelastase—inducedliverinjury糖inhibitingactivationofNF-rd3。Recentlyexperimentalevidencessuggestedthatelastasewasthekeyfactorforactivingsystemicinflammatorycellandthenmagnifiedpancreaticimpartmenttos

3、ystemicinflammatoryresponse．Recently，alargebodyofclinicalandexperimentalstudieshadpayedmuchattentiontotheroleofcytokinesinthepathogenesisofacutepancreatitis-associatedliverinjury．PublishedliteraturesdemonstratedthatKupffercell*derivedtumornecrosisfactor(TNF)

4、inducedacutepancreatitis-associatedliverinjury．However,itcouldn’tcompletelyelucidatetheseverityofhepatocyteinjurybyTNF-inducedapoptosisornecrosis．Uptonow,it’SnotclearthatwhetherotherKupffer-defivedcytokinesinducedliverinjuryduringAP．Fasligand(FasL)，oneofTNFf

5、amilymembers，mediatedhepatocyteapoptosisandplayedimportantroleinIiverinjury．FasLwasmainlyproducedbyactivatedlymphocytessuchasT-lymphocytesandnaturalkillercellswhilealsofunctioningasalleffectorofthesecytotoxiccellstoremoveinfected(virusandbacteria)cellsorneop

6、lasticcells．AlthoughFasL—inducedapoptosisWaSreportedtoplayanimportantroleinparenchymalcelldamageinliverdisease，acuterenalfailure，andthyroiditis，therewaspaucityofinformationregardingtheroleofKupffercell·derivedFasLduringAP．Therefore，theaimofthisstudywastoexpl

7、oreFasLexpressioninKupffercellanditsroleinhepatocyteinjuryduringAPbyELISA，westernblotandhistopathologicalchanges遮cen羹ein-inducedAPinmice．Andthenpretreatment谢thaKupffercellinhibitor,GdCl3，inAPmiceforallinterventionstudy,ABSTItACTcombining、Ⅳimthechangesofliver

8、functionandpathomorphologyoflivertodemonstratetheinteractionsbetweenKupffercellsandhepatocytes，furtherclarifythepathogenesisofacutepancreatitis-associatedliverinjury,finallyprovideapromisingclin