益肾降压颗粒对老年男性高血压病肾气亏虚证患者il-2、leptin影响的研究

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1、提要本研究出自国家自然科学基金项目“补肾方药干预老年人高血压病肾气亏虚证性激素受体表达及调控机制的研究”（No.30873247）。目的：探讨中医肾气亏虚在高血压发病中的作用和机理，以及补肾法对老年男性高血压病患者血清白介素2、瘦素、血压的影响和对临床症状的改善，为补肾法治疗老年男性高血压病提供新的理论根据。方法：临床试验选择符合纳入标准的老年男性,健康人组（20人）、肾气亏虚组（20人）、肝火上炎组（20人）。分别用酶免法和放免法测定三组的白介素2、瘦素水平观察统计。给予肾气亏虚组益肾降压颗粒治疗，4周为一个疗程，观察其治疗前后白介素2、瘦素水平及临床疗效

2、。结果：临床研究显示，肝火上炎组和肾气亏组较健康人组血清白介素2、瘦素水平均有上升，有统计学意义。肾气亏虚组经益肾降压颗粒治疗后，不仅具有良好的降压、改善临床症状的疗效，还使得治疗前后血清瘦素下降，有显著的统计学意义，值得临床广泛应用。结论：益肾法是治疗老年人高血压病的重要法则，益肾降压颗粒是临床治疗老年男性高血压病肾气亏虚证的有效方剂。关键词老年男性高血压病；肾气亏虚证；白介素2、瘦素；益肾降压颗粒；临床研究ResearchontheinfluenceofYiShenJiangYaGranuleonIL-2,Leptinoftheelderlymalepa

3、tientswithhypertensionofKidneyQi-deficiencysyndromeSpecialty:Thestudyofcardiovasculardiseases,InternalmedicineofTCMAuthor:HanXiaojieTutor:ProfessorGuoWeixingAbstractThestudycomesfromthenationalnaturalsciencefoundation“qi-deficiencyinterventionfillingkidneydeficiencyelderlyhypertens

4、ionsyndromesexhormonereceptorcasekidney-qiexpressandcontrolmechanismresearch”.Objective:ToobservethecurativeeffectandprimarymechanismofkidneyQi-deficiencysyndromeinthemorbidityofhypertensionandtheinfluenceoffillingkidneyonIL-2,Leptin,bloodpressureandtheimprovementofclinicalsymptoms

5、andfurthertoprovideanewtheoreticalbasisonthetreatmentofelderlyprimaryhypertensionthroughtheTCMtheoryoffillingkidney.Methods:Intheclinicalstudy,60elderlymalepatientsofhypertensionweredividedinto3groups:20casesinthehealthgroup,20casesinthekidneyqi-deficiencysyndromegroupand20casesint

6、heliver-fireascendinggroup.UseenzymeimmunoassayandradioimmunoassayinthreegroupstomeasurethelevelsofIL-2andleptinandtoobserveandstatistics.Theqi-deficiencykidneygroupwastreatedbyYiShenJiangYaGranuleand4weekstobeacourseoftreatment.ObservethelevelsIL-2andleptinbeforeandafterthetreatme

7、ntandclinicalefficacy.Results:ClinicalstudiesshowthatIL-2andleptinlevelsofkidneyqi-deficiencysyndromegroupandliver-fireascendinggrouprisedthanthehealthgroupandshowingsignificantdifferences.AfterthetreatmentofYiShenJiangYaGranule,thekidneyqi-deficiencysyndromegrouphasnotonlygoodcura

8、tiveeffectofdecliningblood