apelin-13对大鼠局灶性脑缺血—再灌注损伤的保护作用与其机制

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1、万方数据ischemia-reperfusiongroup，thewatercontentofbraintissue，thevolumeandrateofinfarctweresignificantlydecreasedindosedependentmannerintheApelin·13(1．0and10．0ug&g)group(allP<0，05)。(3)Thestructureofbrainofratswasnormal，thenucleusofneuronwaslocatedinthecentreofc

2、ells，thedegenerationandnecrosisofneuronwerenotobservatedintheshamgroup．Comparedwiththeshamgroup，theamountofneuronwassignificantlydecreasedintheischemia—reperfusiongroup．Thetissueedema，thedegenerationandnecrosisofneuron，thekaryopyknosisandcaryolysisofnucleusw

3、ereobservatedinthegroup．Comparedwiththegroup，thestructureofbrainofratswasimproved，thedegreeofedema，karyopyknosisandcaryolysisofnucleuweresignificantlydecreasedandtheamountofdegenerationandnecrosisofneuronweresignificantlydecreasedintheApelin-13(1．0and10．0gg／

4、kg)group．(4)Comparedwiththegroup．theIevelofMDAandtheIevelofROSinthetissuebomogenateofbraintissueinthesurroundingareaofischemiaweresignificantlydecreasedindosedependentmannerintheApelin-13(1．0and10．0pg瓜曲group(allP

5、evelofGSHinthetissuebomogenateofbraintissueinthesurroundingareaofischemiaweresignificantlyincreasedindosedependentmannerintheApelin一13(1．0and10．0gg／kg)(allP

6、sueinthesurroundingareaofischemiaweresignificantlyup·regulatedindosedependentmannerintheApelin-13(1．0and10．0gg／kg)(allP<0．05)．Conclusion：Apelin-13protectstheinjury，whichthemechanismsmayberelatedwiththeinhibitionofoxidativestressandup—regulationofBDNFandTrkBi

7、nducedbyApelin-13．12figures，1tables，73references．Keyword：Apelin·13；Brainischemia—reperfusioninjury；Totalantioxidantcapacity；Reactiveoxygenspecies；MalondiaidehydeClassfication：R743V万方数据目录学位论文原创性声明．．．⋯⋯．⋯⋯⋯．⋯⋯⋯⋯⋯⋯⋯．⋯⋯．．I中文摘要．⋯⋯⋯⋯．⋯⋯⋯．⋯⋯⋯⋯⋯．⋯⋯⋯⋯．⋯⋯II英文摘要⋯⋯⋯⋯．⋯．

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