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1、按ISTH评分诊断的弥散性血管内凝血患者的临床特征分析武汉大学人民医院杨婷1高清平通信作者:高清平,E-mail:13006126285@163.com,武汉430060摘要目的:探讨按国际血栓与止血协会(ISTH)评分诊断的弥散性血管内凝血(DIC)患者的临床表现、诊断、治疗及预后特征。方法:回顾性分析我院按ISTH评分诊断的928例DIC患者的临床资料,包括原发病、临床表现、止凝血指标、治疗及预后等。结果:40.63%出现不同程度出血,38.04%出现休克,56.36%出现器官衰竭。感染占DIC原发病比例最高(44.40%),感染并发DIC器官衰竭发生率最高
2、(62.62%);病理产科DIC出血率最高(76.92%),休克率最高(73.08%),有效率最高(65.38%),死亡率最低(0.00%);恶性肿瘤DIC死亡率最高(35.88%),与总计发生率相比差异显著(P<0.05)。有效组和无效组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及D-二聚体(DD)比较差异显著(P<0.05),纤维蛋白原浓度(FIB)及血小板(PLT)最低值比较差异不显著(P>0.05)。PLT下降率越高,DIC患者有效率越低,且差异显著(P<0.05);ISTH显性积分越高,DIC患者有效率越低,且差异显著(P<0.05)。结论
3、:出血是DIC典型的临床表现,器官衰竭更为常见;感染占DIC原发病比例最高,感染并发DIC器官衰竭发生率最高,病理产科DIC出血及休克发生率最高但预后最好,恶性肿瘤DIC预后最差;PT、APTT、DD、PLT下降率及ISTH显性积分有助于提示DIC患者的预后。关键词弥散性血管内凝血ISTH显性积分止凝血指标Analysis the clinical features of patients with disseminated intravascular coagulation diagnosed by ISTH scoringYangTing1,GaoQing-
4、ping*.RenminHospitalofWuhanUniversity,Wuhan430060,ChinaAbstractObjective:Toinvestigatetheclinicalfeatures,diagnosis,treatmentandprognosticfactorsofdisseminatedintravascularcoagulationdiagnosed(DIC)byISTHscoring.Method:Clinicaldataof928patientswithDIC,includingtheunderlyingdisease,cli
5、nicalmanifestations,hemostaticindicators,treatmentandprognosiswhodiagnosedwithDICaccordingtoISTHscoringinourhospitalwereanalyzedretrospectively.Result:40.63%haddifferentdegreesofhemorrhage,38.04%hadshock,56.36%werecombinedorganfailure.Infectionaccountedforthehighestproportionofprimar
6、ydiseasewithDIC(44.40%),thehighestorganfailurerate(62.62%);pathologyobstetricsgrouphadthehighestbleedingrate(76.92%),highestshockrate(73.08%)thehighestefficiency(65.38%),thelowestmortalityrate(0.00%);thehighestmortalityrate(35.88%)ofmalignanttumorsgroup,comparedwiththetotalincidenceo
7、fthedifferenceswerestatisticallysignificant(P<0.05).EffectivegroupandineffectivegroupofProthrombintime(PT),activatedpartialthromboplastintime(APTT)andD-dimer(DD)weresignificantlydifferent(P<0.05),fibrinogenconcentration(FIB)andplatelet(PLT)lowestvaluecomparedtothelackofstatisticallys
8、ignificantdi