急性肾炎精品医学ppt课件

《急性肾炎精品医学ppt课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、AcuteGlomerulonephritisEdemaHematuriaHypertensionConvulsionAnti–o↑C3↓proteinuriaThisglomerulusishypercellularandcapillaryloopsarepoorlydefined.Thisisatypeofproliferativeglomerulonephritistheimmunedepositsaredistributedinthecapillaryloopsinagranular,bumpypatternbecauseofthefocalnatureo

2、fthedepositionprocessDiagonosis?Why?edemaproteinuriaHematuriahypertension.AcuteGlomerulonephritisBackgroundCausesPathophysiologyClinicalmanifestationDiagonosisDifferetionaldiagonosisTratmentprogonosisBackgroundAtypicalonsetedemahematuriaproteinuriahypertensionPersistentlydepressedC3(p

3、ast8-10wk)PathophysiologyandClinicalmanifestationstreptococcalantigensspecificantibodies→activatethecomplementsystemc3↓Variouscytokinesothercellularimmunityfactors→glomerularbasementmembrane→→bloodefusionHematuriaProteinuriacastVariouscytokines→proliferationofmesangialandepithelialcel

4、ls→glomerularperfusion↓,glomerularfiltrate(GF)-↓Severeoliguria,renalfailureglomerularfiltrate(GF)↓---H2O,Na+sterve-----bloodvolume↑edemahypertentioncirculatorycongestionencephalopathy.PathologyThehypercellularityofpost-streptococcalglomerulonephritisisduetoincreasednumbersofepithelial

5、,endothelial,andmesangialcellsaswellasneutrophilsinandaroundthecapillaryloops.ThisdiseasemayfollowseveralweeksafterinfectionwithcertainstrainsofgroupAbetahemolyticstreptococci.Post-streptococcalglomerulonephritisisimmunologicallymediated,andtheimmunedepositsaredistributedinthecapillar

6、yloopsinagranular,bumpypatternbecauseofthefocalnatureofthedepositionprocess.ClinicalmanifestionSexAgeHistoryGrosshematuriaedemaHypertension1Circulatorycongestion2Hypertensiveencephalopathy3Acuterenalfailure