哮喘儿童血清白介素水平的循证评价

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1、维普资讯http://www.cqvip.com31卷第1O期JiangsuMedJ，October2005，Vol31，No．10论著哮喘儿童血清白介素水平的循证评价徐美玉季健玲【摘要】目的评价儿童哮喘患者血清中II『4、IL-6、IL-8检测指标的意义。方法通过中国生物医学文献数据库(CBMdisc)、中文全文数据库全面检索国内已发表的文献，选择中国儿童哮喘患者与对照组血II．-4、IL-6、II．-8水平检测，由2位评价者按照上述检索策略收集文献，进行Meta分析。结果儿童哮喘患者发作期、缓解期血清中II，4分别较对照组上升89．99ng／L(95CI47．13～132．84)、25．

2、82ng／L(95CI15．78~35．86)(P

3、medicineofresearchontheseruminterleukinsinchildrenwithasthmaXUMeiyu，JIJianling．DepartmentofPediatrics，AffiliatedHospital，NantongUniversity，Nantong226001，CHlNA[AbstractlObjectiveToevaluatethesignificanceofinterleukin(IL)一4，II一6andIL-8measure—mentsinchildrenwithasthm&MethodTheanalysisofallrelatedlite

4、raturesinCBMdiscandChinesefulltextdatabasehasbeenmade．SelectioncriteriaweretheexaminationsofserumIL，4。IL一6andIL-8inChinesechildrenwithasthmaandcontro1groups．Aquantitativemeta—analysiswascarriedOUtbytworeviewsusingupdateinformationbasedoninclusionandexclusioncriteriafromthepapersavaila～ble．ResultsTh

5、econcentrationsofIL-4duringattackphaseandcatabaticphaseinthepatientsweresignificantlyhigherthanthoseinthehealthysubjects，whichwereincreasdby89．99ng／I(95CI47．13～132．84)and25．82ng／I(95CI15．78～35．86)(P

6、1)and183．15ng／1(95C1104．58～261．72)，whichwerehigherthanthoseinthehealthysubjects(P

7、andIL-8playaroleinthepatho—physiologicalprocessinChinesechildrenwithasthma．[KeywordslAsthma；Children；Interleukin；Evidence-basedmedicine；Meta—analysisI．，／angsuMedJ，October2005，31(10)：741．742．f近年来儿童哮喘患病率有上升趋势