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2、薅肅膈莂袄肅芀薇螀肄莃莀蚆肃肂薆薂蝿膅荿蒈螈芇薄螆螈羇莇螂螇腿蚂蚈螆芁蒅薄螅莃芈袃螄肃蒃蝿螃膅芆蚅袂芈蒂薁袂羇芅蒇袁肀蒀袆袀节莃螂衿莄薈蚈袈肄莁薄袇膆薇蒀袆艿荿螈羆羈薅蚄羅肁莈薀羄芃薃薆羃莅蒆袅羂肅艿螁羁膇蒄蚇羀艿芇薃羀罿蒃葿聿肁芅螇肈膄蒁蚃肇莆芄虿肆肆蕿薅肅膈莂袄肅芀养血清脑颗粒治疗脑动脉硬化性头痛的临床研究李敬诚1王延江1周华东1邓娟1高长越1田玉静2兰进军2陈曼娥1(1第三军医大学大坪医院脑二科,2核医学科重庆400042)摘要:目的观察养血清脑颗粒对脑动脉硬化性头痛的疗效,并探讨其机制。方法127名脑动脉硬化性头痛患者随机分为治疗组和对照组,观察疗效、T
3、CD及血浆一氧化氮(NO)、降钙素基因相关肽(CGRP)、内皮素(ET)和β-内啡肽(β-EP)水平的变化。结果(1)治疗组的显效率和有效率明显高于对照组;(2)治疗组起效时间明显短于对照组;(3)两组在治疗1月后NO、CGRP和β-EP水平增高,ET和VM下降,治疗组的变化幅度显著大于对照组;(4)治疗组疗效与NO、CGRP、β-EP、ET和VM的变化显著相关。结论养血清脑颗粒对脑动脉硬化性头痛疗效确切,药理机制可能是通过NO、CGRP、ET和β-EP来发挥治疗作用。关键词:养血清脑颗粒;脑动脉硬化性头痛;临床疗效AClinicalStudyofYangxue
4、qingnaokeliinTreatmentofCerebralArterioscleroticHeadacheJingchengLi1,JohnY.J.Wang1,DavidH.D.Zhou1,JuanDeng1,ChangyueGao1,YujingTian1,JinjunLan1,Man’eChen1(12ndDepartmentofNeurology,2Departmentofnuclearmedicine,DapingHospital,ThirdMilitaryMedicalUniversity,Chongqing400042)AbstractObje
5、ctive:ToinvestigatethetherapeuticefficacyofYangxueqingnaokeliinpatientswithcerebralarterioscleroticheadache.Methods:127patientswithcerebralarterioscleroticheadacheaged50to75wererandomlydividedintotherapeuticgroupandcontrolgroup,thetherapeuticefficacyandconcentrationofserumnitricoxide
6、(NO),calcitoningeng-relatedpeptide(CGRP),endothelin(ET),β-endorphin(β-EP)andaveragevelocityofcerebralbloodflow(VM)weremeasured.Results:(1)Theeffectiverateoftherapeuticgroupwassignificantlyhigherthanthatofcontrolgroup;(2)Thetimefortheonsetofheadacheremissionwasshorterintherapeuticgrou
7、pthanincontrolgroup;(3)After30dtreatment,increaseofNO,CGRP,β-EPanddecreaseofET,VMwereobservedinbothgroups,butthesechangesintherapeuticgroupweresignificantlygreaterthanincontrolgroup;7(4)ThetherapeuticefficacywascorrelatedwiththechangeofNO,CGRP,β-EP,ETandVM.Conclusions:Yangxueqingnaok
8、eliisveryeff