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ID:33157772
大小:1.85 MB
页数:41页
时间:2019-02-21
《阻塞性睡眠呼吸紊乱对脑梗死患者脑微出血的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、南昌大学硕士学位论文阻塞性睡眠呼吸紊乱对脑梗死患者脑微出血的影响姓名:徐杰文申请学位级别:硕士专业:神经病学指导教师:邓丽影20120531摘要目的:研究阻塞性睡眠呼吸暂停低通气综合征(obstmctivesleep印nea-h),popneasyndrome,0SAHS)对脑梗死患者脑微出血(cerebralmicrobleeds,CMBs)的影响。方法:连续选取经磁敏感加权成像(susceptibilit)r.weightedimaging,SWI)检查显示为脑微出血的急性脑梗死患者行睡眠多导图(polysomograpllic,P
2、SG)检查,将AHI(apneah),poneaindex,AHI)<5定为非OSAHS组,AHI≥5为OSAHS组。比较非OSAHS患者和OSAHS患者脑微出血的临床及影像学特征。结果:入选49名,其中脑梗死合并OSAHS者27人(55.1%),脑梗死未合并OSAHS组22人(44.9%)。相关危险因素比较显示OSAHS组高血压、吸烟史和既往卒中史明显高于非OSAHS组(P<0.05),而且临床下卒中OSAHS组为37.0%(10/27),非0SAHS为9.0%(2/22)(P<0.05)。神经影像学研究显示0SAHS组较非OSAHS
3、组脑微出血数量多(P<0.05),OSAHS组微出血病灶77.8%分布在脑皮质一皮质下区,55.6%在脑基底节区,幕下区为25.9%;非OSAHS组皮质一皮质下区为50.O%、基底节区为40.9%、幕下区为50.0%(P4、阻塞性睡眠呼吸暂停低通气综合征;脑微出血AbstralctABSTRACTObjectiVe:TbinVestigatemeefrectofobstmstiVesleepapnea-hypopneasyndrome(OSAHS)oncerebralmicrobleeds(CMBs)incerebralinf打ctionpatients.Methods:Patients谢thcerebralmicrobleeds’sacutecerebralinfarctionaccordingtotheresultsofasusc印tibilit),一5、weightedimaging(SWI)ex锄,weresuccessivelychosentounde玛oapolyso脚【nogr锄(PSG).Allpatients、verediVidedt、Vogroup:AHIoflessthan5asnon0SAHSgroup:AHIisequalorgreaterthan5asOSAHSgroupaccordingtosle印印nea-hypopneaindex(AHI).Thisstudycomparedtheclinicalandmdiologicalfeaturesofcerebra6、lmicrobleedsbetweenpatientswith0SAHSandpatients谢tlloutOSAHS.Results:49patients、vereemolledultimately.Amongthem,27patients(55.1%)su仃.er丘.ombothcerebralinfIarctionandOSAHS,aJld22patients(44.9%)havecerebralinfarctionbutdonothaVeOSAHS.Aco瑚Ipansonofriskfactorsshowsthathyperte7、nsion,smokinghistoⅨandtlistoryofstrokearemorepreValentinpatientswithOSAHSthanpatientswithoutOSAHS(P<0.05).Furthe肌ore,thepercentageofsubclinicalstrokeinOSAHSpatients锄dnon-0SAHSpatientsare37.O%(10/27)and9.0%(2/22)(P<0.05),reSpectiVely.Theneurologicalimagingstudyrevealsthat8、menumberofcerebralmicrobleedsinOSAHSgroupismoretllallnon.OSAHS伊oup(P<0.05),77.8%ofmefocusofmicrobleedsi
4、阻塞性睡眠呼吸暂停低通气综合征;脑微出血AbstralctABSTRACTObjectiVe:TbinVestigatemeefrectofobstmstiVesleepapnea-hypopneasyndrome(OSAHS)oncerebralmicrobleeds(CMBs)incerebralinf打ctionpatients.Methods:Patients谢thcerebralmicrobleeds’sacutecerebralinfarctionaccordingtotheresultsofasusc印tibilit),一
5、weightedimaging(SWI)ex锄,weresuccessivelychosentounde玛oapolyso脚【nogr锄(PSG).Allpatients、verediVidedt、Vogroup:AHIoflessthan5asnon0SAHSgroup:AHIisequalorgreaterthan5asOSAHSgroupaccordingtosle印印nea-hypopneaindex(AHI).Thisstudycomparedtheclinicalandmdiologicalfeaturesofcerebra
6、lmicrobleedsbetweenpatientswith0SAHSandpatients谢tlloutOSAHS.Results:49patients、vereemolledultimately.Amongthem,27patients(55.1%)su仃.er丘.ombothcerebralinfIarctionandOSAHS,aJld22patients(44.9%)havecerebralinfarctionbutdonothaVeOSAHS.Aco瑚Ipansonofriskfactorsshowsthathyperte
7、nsion,smokinghistoⅨandtlistoryofstrokearemorepreValentinpatientswithOSAHSthanpatientswithoutOSAHS(P<0.05).Furthe肌ore,thepercentageofsubclinicalstrokeinOSAHSpatients锄dnon-0SAHSpatientsare37.O%(10/27)and9.0%(2/22)(P<0.05),reSpectiVely.Theneurologicalimagingstudyrevealsthat
8、menumberofcerebralmicrobleedsinOSAHSgroupismoretllallnon.OSAHS伊oup(P<0.05),77.8%ofmefocusofmicrobleedsi
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