益髓补血方为主联合atra治疗mds-ra临床疗效的观察

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1、提要目的：观察益髓补血方为主联合全反式维甲酸（ATRA）治疗骨髓增生异常综合征RA型（MDS-RA）的临床疗效及临床症状改善情况。方法：将入选的40例骨髓增生异常综合征RA型患者随机分为2组，分别为实验组和对照组，实验组20例，给予益髓补血方为主联合维甲酸治疗；对照组20例，给予维甲酸治疗，两组均2个月为一疗程，两个疗程后对照观察两组患者治疗前后的临床疗效。结果：1.益髓补血方联合ATRA治疗可有效改善MDS-RA患者贫血、出血症状以及外周血象，并降低外周血和骨髓中幼稚细胞百分比，疗效优于对照组（P<0.05）。2.治疗组患者的中医证

2、候积分改善，明显优于对照组（P<0.05）。结论：采用益髓补血方为主联合维甲酸治疗MDS-RA，可有效改善患者的临床症状和血液学指标，在临床上值得进一步深入研究。关键词益髓补血方；全反式维甲酸；骨髓增生异常综合征；临床疗效ClinicalResearchonTreatingtheMyelodysplasticsyndrome-RefractoryAnemiabyYisuibuxuefangSpeciality：InternalMedicineofTCMAuthor：BaoYichaoTutor：XuRuirongAbstractObj

3、ective:observationonyisuibuxuefangrecipecombinedwithAll-transretinoticacid(ATRA)inthetreatmentofMyelodysplasticsyndromes-RA(MDS-RA)clinicaleffects,andapreliminarystudyonthetherapeuticmechanism,toprovideabasisforclinicaluseofdrugs.Methods:mettheinclusioncriteriaof40patie

4、ntswithmyelodysplasticsyndromeinpatientswithRArandomlydividedintotreatmentandcontrolgroups,treatmentgroup20,invigoratingthespleenandtonifyingkidneypluscombinedwithATRAforreduction;controlgroupof20cases,treatedbysimpleuseofATRA.Twomonthsweredescribedasoneperiodoftreatmen

5、t.Aftertwoperiods，clinicaleffectwasobserved.ObservationofclinicalcurativeeffectoftwogroupsofpatientsbeforeandaftertreatmentandsyndromeoftraditionalChinesemedicinetoimprovethesituation,peripheralbloodcellcounts,percentageofnaivecellsfromperipheralbloodandbonemarrowchange

6、s.Results:clinicalobservation:treatmentgrouptotaleffectiverate75.00%,controlledgrouptotaleffectiverate55.00%,bothZhijianexistssignificantlysexualdifferences(P<0.05);treatmentgroupoftcmcardwaitingintegralimprovesignificantly,obviousbetterthancontrolledgroup(P<0.05);healt

7、hspleensupplementrenalmethodcaneffectiveimprovepatientsanemia,andbleeding,symptoms,improveoutsideweekhemogram,reducebonemarrowinthenaivecellpercentage,butandcontrolledgroupzhijianobviousdifferences(P<0.05).Conclusion:dominatedbyyisuibuxuefangcombinedwithATRAcaneffective

8、lyimprovethepatient'sclinicalsignsandsymptoms,haveabetterclinicalcurativeeffectontreatmentofMDS-RA.KeywordsYis