血清ca153、cea、ca125水平与乳腺癌骨转移的相关性分析

《血清ca153、cea、ca125水平与乳腺癌骨转移的相关性分析》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、硕士学位论文TheclinicalsignificanceofserumCAl53，CEA、CAl25forbreastcancerpatientswithobjectives：bonemetastasesName：lixiuyueSupervisor：ProfLuoRongchengABSTRACT1．Toexplorethepredictivevalueserumcancerantigenl53(CAl53)、carcmo—emb巧omcantigen(CEA)andcancerantigen125(CAl25)forbreas

2、tcancerpatientswithbonemetastases2．Todiscusstherelationshipbetweenbaselinecharacteristics(TNMstage，numberofbonemetastaticregioIl，numberofectostealmetastaticregion，expressionofHER-2(HumanEpidermalGrowthFactorReceptor2)、estrogenreceptor(ER)andprogesteronereceptor(PR)，men

3、opausalstatus)andserumlevelsofCAl53andCEAinpatientswitllbreastcancer．3．ToinvestigatetherelationshipbetweentheserunlCA153，CEAandCA125．andonsettimeofbonemetastasisinbreastcarcinoma．4．Toanalyzetheassociationbetweenbaselinecharacteristics(TNMstage，numberofbonemetastaticreg

4、ion，numberofectostealmetastaticregioIl，expressionofHER-2，ERandPR,enopausalstatus)andonsettimeofbonemetastasis．ABSTRACTMethods：1．ThesampleswereobtainedfromnanfanghospitalandguangzhoupanyucentralhospitalbetweenJune2001andJune2010．140patients(139female，1male)、析tllbreastca

5、ncerconfirmingbypathologywereincluded。WestudyedandanalyzedtheserumlevelofCAl53，CEAandCAl25detectingbyELISA(enzymelinkedimmunosorbentassay)．Theagesofpatientsrangesfrom26to89withthemedianageof50．70patientsdevelopedbonemetastasesafteroperation，64casesoccurredwithin1t05yea

6、rsand6casesformorethan5yearsafteroperation．Amongthem，39patientswereexaminedforserumlevelofCEA、CAl53beforeandafterdiagnosisofbonemetastases．Thecontrolgroupconsistedof70patients、啊thnobonemetastasesforatless5yearsaftertheoperation．Inthe140availablepatients，128Wasdiagnosed

7、ofinfitratingductalcarcinoma(IDC)and12Wasdiagnosedofbreastcancerofothertypes．2．Evaluationcriterionforbonemetastasesinbreastcancer：Breastcancerwasdiagnosed、Ⅳitllpathologicalsectionsofsurgicalspecimen；ECTWasperformedandreviewedbyatleast2nuclearmedicinephysicians．patients

8、withmultiple，sporadic，randomizeddistributingradioactiveconcentratinglesionsandrelevanthistory,symptomsorphisicalsigns