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ID:33083651
大小:5.34 MB
页数:47页
时间:2019-02-20
《血清ca153、cea、ca125水平与乳腺癌骨转移的相关性分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、硕士学位论文TheclinicalsignificanceofserumCAl53,CEA、CAl25forbreastcancerpatientswithobjectives:bonemetastasesName:lixiuyueSupervisor:ProfLuoRongchengABSTRACT1.Toexplorethepredictivevalueserumcancerantigenl53(CAl53)、carcmo—emb巧omcantigen(CEA)andcancerantigen125(CAl25)forbreas
2、tcancerpatientswithbonemetastases2.Todiscusstherelationshipbetweenbaselinecharacteristics(TNMstage,numberofbonemetastaticregioIl,numberofectostealmetastaticregion,expressionofHER-2(HumanEpidermalGrowthFactorReceptor2)、estrogenreceptor(ER)andprogesteronereceptor(PR),men
3、opausalstatus)andserumlevelsofCAl53andCEAinpatientswitllbreastcancer.3.ToinvestigatetherelationshipbetweentheserunlCA153,CEAandCA125.andonsettimeofbonemetastasisinbreastcarcinoma.4.Toanalyzetheassociationbetweenbaselinecharacteristics(TNMstage,numberofbonemetastaticreg
4、ion,numberofectostealmetastaticregioIl,expressionofHER-2,ERandPR,enopausalstatus)andonsettimeofbonemetastasis.ABSTRACTMethods:1.ThesampleswereobtainedfromnanfanghospitalandguangzhoupanyucentralhospitalbetweenJune2001andJune2010.140patients(139female,1male)、析tllbreastca
5、ncerconfirmingbypathologywereincluded。WestudyedandanalyzedtheserumlevelofCAl53,CEAandCAl25detectingbyELISA(enzymelinkedimmunosorbentassay).Theagesofpatientsrangesfrom26to89withthemedianageof50.70patientsdevelopedbonemetastasesafteroperation,64casesoccurredwithin1t05yea
6、rsand6casesformorethan5yearsafteroperation.Amongthem,39patientswereexaminedforserumlevelofCEA、CAl53beforeandafterdiagnosisofbonemetastases.Thecontrolgroupconsistedof70patients、啊thnobonemetastasesforatless5yearsaftertheoperation.Inthe140availablepatients,128Wasdiagnosed
7、ofinfitratingductalcarcinoma(IDC)and12Wasdiagnosedofbreastcancerofothertypes.2.Evaluationcriterionforbonemetastasesinbreastcancer:Breastcancerwasdiagnosed、Ⅳitllpathologicalsectionsofsurgicalspecimen;ECTWasperformedandreviewedbyatleast2nuclearmedicinephysicians.patients
8、withmultiple,sporadic,randomizeddistributingradioactiveconcentratinglesionsandrelevanthistory,symptomsorphisicalsigns
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