二氧化铈纳米颗粒对大鼠心肌缺血再灌注损伤的影响

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1、摘要不如假手术组，存在炎症细胞浸润等现象。3．4心肌细胞凋亡检测结果显示，模型组心肌细胞凋亡指数(apoptoticindex，AI)较假手术组显著升高(尸<0．05)，差异具有统计学意义；三种不同粒径二氧化铈纳米颗粒组AI均明显低于模型组(氏0．05)，差异具有统计学意义，其中10-25nm组AI明显低于另外两组(尸<0．05)，差异具有统计学意义，1．10nm组、50nm组两组之间无显著差异(尸>O．05)。4结论4．1二氧化铈纳米颗粒可显著提高大鼠缺血再灌注损伤心肌组织中SOD、GSH．Px

2、的活性，降低MDA的含量。4．2二氧化铈纳米颗粒明显降低了心肌细胞凋亡的发生，改善了再灌注损伤引起的心肌细胞的形态改变。4．3减轻了大鼠心肌细胞缺血再灌注损伤过程中的氧化应激，对大鼠心肌细胞起到了一定程度的保护作用。关键词：二氧化铈纳米颗粒心肌缺血再灌注损伤超氧化物歧化酶谷胱甘肽过氧化物酶丙二醛细胞凋亡氧自由基IVEffectsofCe02NanoparticlesontheMyocardialIschemicReperfusionInjuryinRatsPostgraduate：RuitaoLv

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