晚期胃癌化疗疗效与安全性的临床分析

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1、万方数据浙江大学硕士学位论文一茎茎塑墨TheclinicalanalysisofefficacyandsafetyofchemotherapyforgastriccancerTheFirstAffiliatedHospital，CollegeofMedicine，ZhejiangUniversitySubjectOncologyPostgraduateYaoWangTutorNongXuAbstractPurposes：Thisretrospectivestudywasperformedtoevaluatetheactivitya

2、ndtoxicityofchemotherapyinpatientswithlocallyadvancedandmetastaticgastricCanCer．Methods：Advancedgastriccancerpatients，whoadmittedtoreceivechemotherapyinDepartmentofMedicalOncologyoftheFirstAffiliatedHospitalofZhejiangUniversitySchoolofMedicinebetweenJanuary1，2010toDec

3、ember31，2012，wereenrolledtothisretrospectivestudy．Patientswereassessedactivityandsafetyprofileaftertreatment．Theefficacyandprognosisrelatedfactorincludingclinicalandpathologicalfeatures，chemotherapyregimen，chemotherapylineswereanalyzed．Results：Forthefirst—linechemothe

4、rapy谢t11atotalof1000cycles，theORRwas35．0％，DCRwas83．3％，themedianPFSwas4．9months(95％CI：4．34-5．46)，themedianOSwas10．4monthsf95％CI：9．06—11．67)．58patientsreceivedonlyfirst-lineIV万方数据浙江大学硕士学位论文英文摘要chemotherapy,themedianOSwas6．9months，45patientsreceived1-2linetreatment，theme

5、dianOSwas12．3months，19patientsreceived1-3linetreatment，themedianOSwas14．4months，15patientsreceived1-4or1-5linetreatment，themedianOSwas15．5months．Thesurvivaltimeofthepatientsacceptonlyfirst—linetherapyand2linetreatmentpatientswerecompared，theresultshowsecond—linetherap

6、yCansignificantlyimprovesurvivaltimerPO．05)，thePFSwas4．4monthsforSOXVS．5．2monthsforSPA(P=0．13)，theOSwas10．3monthsforSOXVS．12．2monthsforSPA(P=0．223)．Insignetringcellcarci

7、noma，poorlydifferentiatedadenocarcinoma，poorlytomediandifferentiatedadenocarcinomacases，TheORRwas14．81％forSOXVS．37．4％forSPA(P<0．05)，thePFSwas4．4monthsforSOXVS．5．2monthsforSPA(P=0．685)，theOSwas10．8monthsforSOXVS．13．5monthsforSPA(P=0．291)．Coxanalysisshowsufficienttreatm

8、ent，tumorresponse，differentiation，first—linePFS，post—progressiontreatmentwereindependentprognosticfactorsinpatientswithadvan