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ID:33010804
大小:2.65 MB
页数:46页
时间:2019-02-19
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1、万方数据浙江大学硕士学位论文一茎茎塑墨TheclinicalanalysisofefficacyandsafetyofchemotherapyforgastriccancerTheFirstAffiliatedHospital,CollegeofMedicine,ZhejiangUniversitySubjectOncologyPostgraduateYaoWangTutorNongXuAbstractPurposes:Thisretrospectivestudywasperformedtoevaluatetheactivitya
2、ndtoxicityofchemotherapyinpatientswithlocallyadvancedandmetastaticgastricCanCer.Methods:Advancedgastriccancerpatients,whoadmittedtoreceivechemotherapyinDepartmentofMedicalOncologyoftheFirstAffiliatedHospitalofZhejiangUniversitySchoolofMedicinebetweenJanuary1,2010toDec
3、ember31,2012,wereenrolledtothisretrospectivestudy.Patientswereassessedactivityandsafetyprofileaftertreatment.Theefficacyandprognosisrelatedfactorincludingclinicalandpathologicalfeatures,chemotherapyregimen,chemotherapylineswereanalyzed.Results:Forthefirst—linechemothe
4、rapy谢t11atotalof1000cycles,theORRwas35.0%,DCRwas83.3%,themedianPFSwas4.9months(95%CI:4.34-5.46),themedianOSwas10.4monthsf95%CI:9.06—11.67).58patientsreceivedonlyfirst-lineIV万方数据浙江大学硕士学位论文英文摘要chemotherapy,themedianOSwas6.9months,45patientsreceived1-2linetreatment,theme
5、dianOSwas12.3months,19patientsreceived1-3linetreatment,themedianOSwas14.4months,15patientsreceived1-4or1-5linetreatment,themedianOSwas15.5months.Thesurvivaltimeofthepatientsacceptonlyfirst—linetherapyand2linetreatmentpatientswerecompared,theresultshowsecond—linetherap
6、yCansignificantlyimprovesurvivaltimerPO.05),thePFSwas4.4monthsforSOXVS.5.2monthsforSPA(P=0.13),theOSwas10.3monthsforSOXVS.12.2monthsforSPA(P=0.223).Insignetringcellcarci
7、noma,poorlydifferentiatedadenocarcinoma,poorlytomediandifferentiatedadenocarcinomacases,TheORRwas14.81%forSOXVS.37.4%forSPA(P<0.05),thePFSwas4.4monthsforSOXVS.5.2monthsforSPA(P=0.685),theOSwas10.8monthsforSOXVS.13.5monthsforSPA(P=0.291).Coxanalysisshowsufficienttreatm
8、ent,tumorresponse,differentiation,first—linePFS,post—progressiontreatmentwereindependentprognosticfactorsinpatientswithadvan
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