晚期胃癌化疗疗效与安全性的临床分析

晚期胃癌化疗疗效与安全性的临床分析

ID:33010804

大小:2.65 MB

页数:46页

时间:2019-02-19

晚期胃癌化疗疗效与安全性的临床分析_第1页
晚期胃癌化疗疗效与安全性的临床分析_第2页
晚期胃癌化疗疗效与安全性的临床分析_第3页
晚期胃癌化疗疗效与安全性的临床分析_第4页
晚期胃癌化疗疗效与安全性的临床分析_第5页
资源描述:

《晚期胃癌化疗疗效与安全性的临床分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库

1、万方数据浙江大学硕士学位论文一茎茎塑墨TheclinicalanalysisofefficacyandsafetyofchemotherapyforgastriccancerTheFirstAffiliatedHospital,CollegeofMedicine,ZhejiangUniversitySubjectOncologyPostgraduateYaoWangTutorNongXuAbstractPurposes:Thisretrospectivestudywasperformedtoevaluatetheactivitya

2、ndtoxicityofchemotherapyinpatientswithlocallyadvancedandmetastaticgastricCanCer.Methods:Advancedgastriccancerpatients,whoadmittedtoreceivechemotherapyinDepartmentofMedicalOncologyoftheFirstAffiliatedHospitalofZhejiangUniversitySchoolofMedicinebetweenJanuary1,2010toDec

3、ember31,2012,wereenrolledtothisretrospectivestudy.Patientswereassessedactivityandsafetyprofileaftertreatment.Theefficacyandprognosisrelatedfactorincludingclinicalandpathologicalfeatures,chemotherapyregimen,chemotherapylineswereanalyzed.Results:Forthefirst—linechemothe

4、rapy谢t11atotalof1000cycles,theORRwas35.0%,DCRwas83.3%,themedianPFSwas4.9months(95%CI:4.34-5.46),themedianOSwas10.4monthsf95%CI:9.06—11.67).58patientsreceivedonlyfirst-lineIV万方数据浙江大学硕士学位论文英文摘要chemotherapy,themedianOSwas6.9months,45patientsreceived1-2linetreatment,theme

5、dianOSwas12.3months,19patientsreceived1-3linetreatment,themedianOSwas14.4months,15patientsreceived1-4or1-5linetreatment,themedianOSwas15.5months.Thesurvivaltimeofthepatientsacceptonlyfirst—linetherapyand2linetreatmentpatientswerecompared,theresultshowsecond—linetherap

6、yCansignificantlyimprovesurvivaltimerPO.05),thePFSwas4.4monthsforSOXVS.5.2monthsforSPA(P=0.13),theOSwas10.3monthsforSOXVS.12.2monthsforSPA(P=0.223).Insignetringcellcarci

7、noma,poorlydifferentiatedadenocarcinoma,poorlytomediandifferentiatedadenocarcinomacases,TheORRwas14.81%forSOXVS.37.4%forSPA(P<0.05),thePFSwas4.4monthsforSOXVS.5.2monthsforSPA(P=0.685),theOSwas10.8monthsforSOXVS.13.5monthsforSPA(P=0.291).Coxanalysisshowsufficienttreatm

8、ent,tumorresponse,differentiation,first—linePFS,post—progressiontreatmentwereindependentprognosticfactorsinpatientswithadvan

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。