脊髓背角胶质细胞在外周神经损伤所致神经病理性痛中的作用

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1、分类号密级国际十进分类号（UDC）第四军医大学博士学位论文脊髓背角胶质细胞在外周神经损伤所致神经病理性痛中的作用周扬培养类别学历研究生申请学位类型学术学位学科(领域)专业麻醉学指导教师徐礼鲜教授（主任医师）指导教师单位口腔医院麻醉科二O一二年五月独创性声明秉承学校严谨的学风与优良的科学道德，本人声明所呈交的论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其他人已经发表或撰写过的研究成果，不包含本人或他人已申请学位或其他用途使用过的成果。与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确的说明并表示了致谢。

2、申请学位论文与资料若有不实之处，本人承担一切相关责任。论文作者签名：日期：保护知识产权声明本人完全了解第四军医大学有关保护知识产权的规定，即：研究生在校攻读学位期间论文工作的知识产权单位属第四军医大学。本人保证毕业离校后，发表论文或使用论文工作成果时署名单位仍然为第四军医大学。学校可以公布论文的全部或部分内容（含电子版，保密内容除外），可以采用影印，缩印或其他复制手段保存论文。学校有权允许论文被查阅和借阅，并在校园网上提供论文内容的浏览和下载服务。同意学校将论文加入《中国优秀博硕士学位论文全文数据库》和编入《中国知识资源总库》，同意按《中国优秀博硕士学位论文全文数据库出版章程》规

3、定享受相关权益。论文作者签名：导师签名：日期：第四军医大学博士学位论文脊髓背角胶质细胞在外周神经损伤所致神经病理性痛中的作用研究生：周扬学科专业：麻醉学所在单位：第四军医大学口腔医学院麻醉科导师：徐礼鲜教授（主任医师）李云庆教授辅导教师：每晓鹏讲师（主治医师）资助基金项目：国家自然科学基金（30901400）关键词：神经病理性痛，脊神经结扎，小胶质细胞，星形胶质细胞，慢性化，Toll样受体3，氯胺酮，Wnt-3a，Frizzled-4，β-catenin中国人民解放军第四军医大学2012年5月第四军医大学博士学位论文目录缩略语表··························

4、·························································1中文摘要···················································································3ABSTRACT···············································································7前言·························································

5、·························11文献回顾··················································································13正文··················································································23实验一脊髓背角小胶质细胞TLR3参与氯胺酮治疗神经病理性痛的研究····························································

6、·······························231材料················································································231.1主要试剂·····································································231.2动物的准备··································································241.3主要仪器··············

7、·······················································242方法················································································242.1鞘内置管和给药····························································242.2脊神经结扎（SNL）模型的制备··········