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ID:32910625
大小:8.27 MB
页数:47页
时间:2019-02-17
《肌骨肿瘤磁共振弥散加权成像应用研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、青岛大学硕士学位论文肌骨肿瘤磁共振弥散加权成像应用研究姓名:庄勋慧申请学位级别:硕士专业:影像医学与核医学指导教师:冯卫华20120602肌骨肿瘤磁共振弥散加权成像应用研究摘要目的:探讨3.OT磁共振弥散加权成像(MR-DWI)对肌骨良、恶性肿瘤的定性诊断的应用价值。方法:收集经手术或穿刺活检获得病理证实的肌骨肿瘤共60例。在3.OTMR扫描仪上进行常规MR扫描和DWI扫描。DWI扫描序列包括并行采集阵列空间敏感度编码技术(arrayspatialsensitivityencodingtechnique,ASSET)校准扫描和单次激励平面回波成像序列(sing
2、le—shotechoplanarimaging,SSEPI),b值取300s/ram2、600s/mm2和900s/mm2。对肌骨良、恶性肿瘤的DwI图像信号进行分析。通过弥散成像自动分析软件建立表观扩散系数(apparentdiffusiontoefficient。ADC)图,分别测量各b值下病变的ADC值,比较良、恶性肿瘤ADC值的差异,并采用受试者操作特征曲线(receiveroperatingcharacteristiccurve,ROC)分析不同b值组ADC值对肌骨良、恶性肿瘤的鉴别诊断效能。结果:①肌骨良、恶性肿瘤的DWl信号在各b值下均无统计学
3、差异(X2=3.791,p>O.05)。②当b值分别为300、600和900s/mm2时,肌骨良、恶性肿瘤的ADC值具有统计学差异04、的诊断效能最大,此时鉴别良恶性肿瘤的最佳ADC阂值为1.26x10-3mm2/s,其敏感度和特异度分别为93.33%和86.67%。结论:弥散加权成像的ADC值对肌骨良、恶性肿瘤具有鉴别诊断价值。不同b值对同一病变ADC值有影响,b=900s/mm2时获得的ADC值诊断效能较高。硕士研究生庄勋慧(影像医学与核医学)指导教师冯卫华教授关键词:磁共振成像;弥散加权成像;骨肿瘤;软组织肿瘤{IlllIIlllUllIllllII{Y2087405ApplicationstudyofMRdiffusionweightedimaginginmusculoskeletal5、tumorsAbstractObjective:Toinvestigatetheappliedvalueof3.0Tmagneticresonancediffusionweightedimaging(MR—DWI)inthequalitativediagnosisofmusculoskeletalbenignandmalignanttumors.Methods:60patientswitllmusculoskeletaltumorspathologicallyconfn'medbysurgeryorbiopsyunderwentconventionalMRIa6、ndDWI(differentbvaluesof300,600and900s/mm2).Arrayspatialsensitivitytheencodingtechnique(ASSET)andsingle-shotechoplanarimaging(SSEPI)sequencewereappliedtoDWI.硼1eDWIsignalintensityofbenignandmalignantmusculoskeletaltumorswitlldifferentbvalueswasanalyzedandtheapparentdiffusioncoefficie7、nt(ADO)valuesofthelesionsweremeasured.ThedifferenceofADCvaluesofmusculoskeletalbenignandmalignanttumorsWascomparedamongdifferentbvalues.Receiveroperatingcharacteristiccurves(ROC)wereanalyzed.Results:①OnDWIimaging,thereWasnosignificantdifferencesofthesignalintensitymusculoskeletalben8、ignandmalignanttumo
4、的诊断效能最大,此时鉴别良恶性肿瘤的最佳ADC阂值为1.26x10-3mm2/s,其敏感度和特异度分别为93.33%和86.67%。结论:弥散加权成像的ADC值对肌骨良、恶性肿瘤具有鉴别诊断价值。不同b值对同一病变ADC值有影响,b=900s/mm2时获得的ADC值诊断效能较高。硕士研究生庄勋慧(影像医学与核医学)指导教师冯卫华教授关键词:磁共振成像;弥散加权成像;骨肿瘤;软组织肿瘤{IlllIIlllUllIllllII{Y2087405ApplicationstudyofMRdiffusionweightedimaginginmusculoskeletal
5、tumorsAbstractObjective:Toinvestigatetheappliedvalueof3.0Tmagneticresonancediffusionweightedimaging(MR—DWI)inthequalitativediagnosisofmusculoskeletalbenignandmalignanttumors.Methods:60patientswitllmusculoskeletaltumorspathologicallyconfn'medbysurgeryorbiopsyunderwentconventionalMRIa
6、ndDWI(differentbvaluesof300,600and900s/mm2).Arrayspatialsensitivitytheencodingtechnique(ASSET)andsingle-shotechoplanarimaging(SSEPI)sequencewereappliedtoDWI.硼1eDWIsignalintensityofbenignandmalignantmusculoskeletaltumorswitlldifferentbvalueswasanalyzedandtheapparentdiffusioncoefficie
7、nt(ADO)valuesofthelesionsweremeasured.ThedifferenceofADCvaluesofmusculoskeletalbenignandmalignanttumorsWascomparedamongdifferentbvalues.Receiveroperatingcharacteristiccurves(ROC)wereanalyzed.Results:①OnDWIimaging,thereWasnosignificantdifferencesofthesignalintensitymusculoskeletalben
8、ignandmalignanttumo
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