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1、提要目的：观察补肾解毒合剂对肝肾阴虚、湿毒内蕴证型慢性乙型肝炎病毒（HBV）携带者疗效的影响，评价中药复方治疗慢性HBV携带者的临床疗效。方法：临床以68例慢性HBV携带者为研究对象，随机分为试验组45例（补肾解毒合剂组）和对照组23例（肌苷片﹢维生素C片治疗组）。观察患者治疗24周后的临床证候、生化指标、病毒学指标、生活质量等的改善情况。结果：治疗24周时试验组总有效率35.56%，对照组为4.35%，总疗效试验组优于对照组(P<0.05)，差异有统计学意义。试验组在改善中医证候、HBV-DNA转阴率、抗病毒应答率方面明显优于对照组，有统计学差异(P<0.
2、05)；生存质量方面，在躯体健康、躯体角色功能、精力、社会机能及心理健康5个维度改善方面亦有统计学差异；而在HBeAg转阴率、HBeAg/HBeAb转换率方面，两组比较虽无统计学差异，试验组仍表现出一定的治疗优势。结论：补肾解毒合剂治疗肝肾阴虚、湿毒内蕴证的慢性HBV携带安全有效，一定程度上改善患者临床证候及生活质量、提高抗病毒的应答率。关键词补肾解毒合剂；慢性乙肝病毒携带；生活质量；肝肾阴虚、湿毒内蕴证EfficacyObservationontheTreatmentofChronichepatitisBviruscarriersbyBushenjiedu
3、DecoctionSpeciality:ClinicalStudyofTCMAuthor:YangJinglinTutor:Pro.SunJianguangAbstractPurpose：ToobservetheclinicalefficacyofChinesemedicinecompoundintreatingChronichepatitisBviruscarriers,bytheeffectofBushenJieduDecoctiononChronichepatitisBviruscarriersastheentrypoint。Method：Asasub
4、jectofstudyof68patientswithChronichepatitisBviruscarrierswererandomlydividedintotwogroups.Theexperimentalgroup（45cases）wastreatedwithBushenJieduDecoction,andthecontrolgroup（23cases）wastreatedwithInosinetabletsandVitaminCtablets.Afterthetreatmentof24weeks,toobservetheimprovementinpa
5、tientsfollowingas:clinicalsymptom,biochemicalindicators,Pathogenindicators,qualityoflifeandsoon.Results：Afterthetreatmentof24weeks,thetotalefficiencyintheexperimentalgroupwas35.56%,whichwashigherthaninthecontrolgroup4.35%.Statistically,therewasdifferencebetweenthetwogroups(P<0.05).
6、Theexperimentalgroupwassignificantlybetterthanthecontrolgroupinimprovingclinicalsymptom,andanti-viralresponserate,whichwerestatisticallydifferences(P<0.05).TheimprovementofQOLisstatisticallysignificantdifferencesinPhysicalFunctioning,RolePhysical,Vitality,SocialFunctioning，MentalHe
7、alth;IntheHBV-DNAnegativerate,HBeAgnegativerateandHBeAg/HBeAbconversionrate,theexperimentalgroupwashigherthantheother,butinadditiontothetwogroupofHBV-DNAdecline>2lgP<0.05,withstatisticalsignificancedifferenceat24week,Ithadnostatisticdifference(P>0.05).Conclusion：Thetreatmentmethodo
8、fBushenJieduDecoctionissaf
