解毒化瘀颗粒治疗慢性重型肝炎临床研究

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1、学校代码：10600学号：092035学位类型：专业学位广西中医药大学硕士学位论文解毒化瘀颗粒治疗慢性重型肝炎临床研究研究生：宾容导师：毛德文院系（部所）：第一临床医学院专业：中医内科学研究方向：中医药防治肝病完成日期：2012年04月30日目录中文摘要···············································1英文摘要···············································2引言··························

2、··························4正文····················································51资料与方法··········································51.1总体设计············································51.2对照研究·············································51.3研究对象············

3、·································51.4诊断标准···········································51.5研究病例标准······································71.6临床研究实施方案·································81.7观察指标···········································91.8评价指标···················

4、·······················101.9统计分析··········································112结果·················································143讨论·················································274存在问题和展望·····································30结论······················

5、······························32参考文献···············································33附录····················································35综述····················································36致谢····················································45攻读

6、学位期间发表的学术论文目录····················46作者声明···············································47个人简历···············································48中文摘要目的：通过对慢性重型肝炎患者进行中西医结合综合治疗，明确解毒化瘀颗粒治疗慢性重型肝炎的临床疗效；并探讨其治疗慢性重型肝炎的疗效机制和作用靶点；减少慢性重型肝炎并发症的发生率，最终达到降低病死率的目标。方法：采用临床随机对

7、照的设计方法，观察广西中医药大学第一附属医院、广西中医药大学附属瑞康医院2010年06月至2011年10月期间住院接受治疗的63例慢性重型肝炎患者中西医治疗(治疗组)与西医治疗(对照组)前后的病情变化。其中治疗组37例，对照组26例。结果:治疗组治疗8周后在黄疸消退时间、凝血酶原活动度上升至40%以上时间、死亡患者发病后存活时间上与对照组有显著性差异（P<0.05）。在中医症状改善率、中医证候疗效评价上与对照组有显著性差异（P<0.05）。治疗组在改善ALT、AST、CHE等指标上与对照组无显著性差异（P

8、>0.05）。在降低病死率、改善症状、减少并发症方面体现优势。结论：在西医综合治疗基础上，解毒化瘀颗粒在消退黄疸、恢复凝血功能、延长存活时间、改善临床症状等方面疗效明显，较单纯西医综合治疗有一定优势。关键词：解毒化瘀颗粒；慢性重型肝炎；中医药；临床疗效-1-JieduhuayuparticletreatmentofChronicseverehepatitisClinicalresearchAbstractObjective:C