补肾活血熄风方治疗血管性帕金森综合征的临床研究

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1、目的：探讨补肾活血熄风方治疗血管性帕金森综合征（VPS)患者的临床有效性和安全性，从而拓宽中医药治疗VPS的新思路及方法。方法：选取符合标准的病例60例，随机分为治疗组和对照组各30例。治疗组予补肾活血熄风方，水煎服日一剂：对照组予美多芭125-250mg/天口服。两组均治疗8周后观察治疗前后临床症状与体征的变化情况，评定国际通用统一帕金森病评定量表(UPDRS)评分，以此来判定临床疗效，并观察其安全性。结果：治疗后的UPDRS评分均较治疗前有明显降低，经t检验，PC0.0L提示治疗组的临床疗效明显优于对

2、照组。结论：补肾活血熄风方治疗VPS的临床疗效显著，对改善VPS患者的症状、UPDRS评分及延缓疾病进展均有一定的作用。关键词血管性帕金森综合征：补肾活血熄风方：UPDRS评分；临床研究ClinicalResearchonTreatmentoftheVascularParkinsonSyndromebyBushenHuoxueXifengFangSpeciality:theclinicalstudyofneuro-medicaldiseaseofTCMAutlior:RenWenwenTutor:Prof

3、.SunLijunAbstractObjective:ThediscussioninvigoratesBushenHuoxueXifengFangtreatmentthevascularparkinsonsyndromepatient'sclinicalvalidityandthesecurity,forthedevelopmentChinesemedicinetreatmentvascularparkinsonsyndromenewmentalityandmethod.Methods:Theselect

4、ionofstandardcase60cases,wererandomlydividedintotreatmentgroupandcontrolgroupwith30casesineachgroup.ThetreatmentgroupwasgivenBushenHuoxueXifengFang.Shuijianbidayagent;thecontrolgroupwasgivenMadopar,adailxoraldoseof125-250mg.Bothgroupsweretreatedafter8week

5、sofobservationonclinicalsymptomsandsignsofchangesbeforeandaftertreatment,assessmentofinternationalunifiedParkinson'sDiseaseRatingScale(UPDRS)scores,inordertodeterminetheclinicalcurativeeffectandobservationonitssecurity.Results:Aftertreatmentofinternationa

6、lunifiedParkinson'sDiseaseRatingScalescorethanbeforetreatmentisobviouslydecreased,byStudent'sttest.P<0.01,promptingthecurativeeffectoftreatmentgroupwassuperiortocontrolgroup.Conclusion:；BushenHuoxueXifengFangTreatmentofvascularparkinsonismsignificantclini

7、caleffect,toimprovesthevascularparkinsonsyndromepatient'ssymptom，internationalgeneralunificationparkinsonsicknessevaluationmetergradingandpostponementdiseaseprogresseshascertainfunction.KeywordstheVascularParkinsonsyndrome(VPS);BushenHuoxueXifengFang;inte

8、mationalunifiedParkinson'sDiseaseRatingScale(UPDRS)score:clinicalresearch目录临床研究........一、研究对象(一）诊断标准2(二）纳入标准2(三）排除标准3(四）剔除标准3〔五）治疗方法3(六）疾病疗效判定标准3(七）统计学处理4三、临床资料及研究结果4(一）两组性别比较4(二）两组文化程度比较4('三）两组间年龄比较4(四）两组间Hoehn—Yah