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ID:32846259
大小:11.45 MB
页数:119页
时间:2019-02-16
《磁共振磁敏感加权成像观察阿尔茨海默病患者脑内铁质沉积特点》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、中南大学博士学位论文磁共振磁敏感加权成像观察阿尔茨海默病患者脑内铁质沉积特点姓名:章熠申请学位级别:博士专业:神经病学指导教师:杨晓苏;廖伟华20120525八年制博士学位论文中文摘要目的:通过磁共振磁敏感加权成像(Susceptibility-WeightedImaging,SWI)检测阿尔茨海默病(Alzheimer,AD)患者脑铁沉积特点及其与简易智能量表(mini.mentalstateexamination,MMSE)评分、日常生活能力量表(activityofdailyliving,ADL)评分、临床痴呆评定量表(ClinicalDementi
2、aRating,CDR)评分的相关性,探讨AD患者脑内铁沉积特点,及其与病情的关系。方法:研究对象分为AD病例组与对照组,AD病例组根据美国国立神经病、语言交流障碍和卒中研究所.老年性痴呆及相关疾病学会(NationalInstituteofNeurologicalandCommunicativeDisordersandStrokeandtheA1zheimer’SDiseaseandRelatedDisordersAssociation,NINCDS—ADI①A)阿尔茨海默病的诊断标准进行诊断,对照组为与病例组年龄、性别匹配的认知正常者。采用病例对照方法
3、,分析病例组与对照组一般资料及其他辅助检查资料,包括受教育程度、居住环境、职业、嗜好(吸烟、饮酒、饮茶)、其它疾病史(高血压病史、冠心病病史、糖尿病病史)、痴呆家族史、血液生化检查(血糖、总胆固醇(totalcholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白(10wdensitylipoprotein,LDL)、高密度脂蛋白(highdensitylipoprotein,HDL)、血常规、肝功能、肾功能、甲状腺功能三项)、颈部血管彩超结果(颈部动脉斑块、颈部动脉粥样硬化、颈部血管狭窄),及其与AD发病的相关性;分析两组
4、的MMSE、ADL八年制博士学位论文中文摘要评分结果;将研究对象进行MRSWI扫描,比较病例组与对照组各感兴趣区(RegionofInterest,ROI)相位值,并对病例组ROIxU.相位值与MMSE评分、ADL评分、CDR评分的相关性进行分析。结果:共收集AD患者60例,年龄、性别匹配的认知正常者60例。病例组与对照组的一般资料及辅助检查资料的分析显示:病例组的痴呆家族史阳性率、血TC、TG、颈部动脉粥样硬化、颈部动脉狭窄率均高于对照组,与AD发病显著相关(P5、组双侧海马、尾状核、壳核、丘脑,右侧小脑齿状核,左侧苍白球、额叶白质的相位值,较对照组显著降低,差异有统计学意义(P6、,磁共振磁敏感加权成像,铁沉积八年制博士学位论文英文摘要ABSTRACTObjective:TheprimarypurosesofthisarticleweretoinvestigatefeaturesofirondepositioninbrainofpatientswithAlzheimer’Sdiseasebysusceptibility—weightedimaging(swi),andcorrelationofbrainironconcentrationtomini-mentalstateexamination(MMSE),activityofdai7、lyliving(ADL),clinicaldementiarating(CDR).Methods:TheparticipantsincludedADgroupandnormalcontrolgroup,ageandsexmatched.ADpatientswerediagnosedaccordingtoNationalInstituteofNeurologicalandCommunicativeDisordersandStrokeandtheAlzheimer’SDiseaseandRelatedDisordersAssociation(NINCDS-A8、DRDA).TotheprevalencerateofAD,the
5、组双侧海马、尾状核、壳核、丘脑,右侧小脑齿状核,左侧苍白球、额叶白质的相位值,较对照组显著降低,差异有统计学意义(P6、,磁共振磁敏感加权成像,铁沉积八年制博士学位论文英文摘要ABSTRACTObjective:TheprimarypurosesofthisarticleweretoinvestigatefeaturesofirondepositioninbrainofpatientswithAlzheimer’Sdiseasebysusceptibility—weightedimaging(swi),andcorrelationofbrainironconcentrationtomini-mentalstateexamination(MMSE),activityofdai7、lyliving(ADL),clinicaldementiarating(CDR).Methods:TheparticipantsincludedADgroupandnormalcontrolgroup,ageandsexmatched.ADpatientswerediagnosedaccordingtoNationalInstituteofNeurologicalandCommunicativeDisordersandStrokeandtheAlzheimer’SDiseaseandRelatedDisordersAssociation(NINCDS-A8、DRDA).TotheprevalencerateofAD,the
6、,磁共振磁敏感加权成像,铁沉积八年制博士学位论文英文摘要ABSTRACTObjective:TheprimarypurosesofthisarticleweretoinvestigatefeaturesofirondepositioninbrainofpatientswithAlzheimer’Sdiseasebysusceptibility—weightedimaging(swi),andcorrelationofbrainironconcentrationtomini-mentalstateexamination(MMSE),activityofdai
7、lyliving(ADL),clinicaldementiarating(CDR).Methods:TheparticipantsincludedADgroupandnormalcontrolgroup,ageandsexmatched.ADpatientswerediagnosedaccordingtoNationalInstituteofNeurologicalandCommunicativeDisordersandStrokeandtheAlzheimer’SDiseaseandRelatedDisordersAssociation(NINCDS-A
8、DRDA).TotheprevalencerateofAD,the
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