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1、提要目的：本课题旨在通过观察运用参芪地黄汤加味治疗激素抵抗型肾病综合征气阴两虚，络瘀湿阻证的临床研究，观察中医药治疗激素抵抗型肾病综合征的临床疗效和安全性，探求激素抵抗型肾病综合征的最优治疗方法。方法:将60例符合激素抵抗型肾病综合征的患者，随机分为治疗组和对照组，各30例，对照组予以强的松经典疗法及雷公藤多甙片治疗；治疗组：在对照组治疗的基础上加用参芪地黄汤加味。两组均治疗六个月，观察两组的24小时尿蛋白定量、血脂、血浆白蛋白、及肾功能、血流变、肝功能、血常规、尿常规、心电图及中医证气阴两虚、络瘀湿阻的症状积分变化，比较其疗效差异。结
2、果：治疗组治疗后，患者24小时尿蛋白、血浆白蛋白、血脂、血流变、中医临床症状积分等均较治疗前有明显改善，与对照组比较有显著差异。参芪地黄汤加味对患者血常规、肾功能、心电图、肝功均无不良影响。结论：参芪地黄汤加味联合雷公藤多甙片治疗激素抵抗型肾病综合征疗效显著，可以显著改善患者临床症状，降低强的松及雷公藤多甙片的副作用，防治并发症。在临床应用上参芪地黄汤加味是安全有效的，是治疗激素抵抗型肾病综合征的较好方法之一，正确运用参芪地黄汤加味治疗激素抵抗型肾病综合征具有广阔的前景。关键词激素抵抗型肾病综合征；参芪地黄汤加味；临床研究TheClin
3、icalResearchofShenQiDiHuangDecoctionJiaWeionTreatmentSteroid-resistanceNephroticSyndromeSpeciality:ResearchontheUrinarysystemtreatmentwithTCMAuthor:WenWenLiuTutor:Prof.AnqinJiaoAbstractObjective:ThissubjectaimstouseShenqidihuangdecoctiontreatmentofsteroid-resistantnephro
4、ticsyndromeQiyinliangxubyobservingthenetworkstasisdampnesspermitclinicalresearchtoobservetheclinicalefficacyandsafetyofChinesemedicineintreatmentofsteroid-resistantnephroticsyndrome,exploretheoptimaltreatmentofsteroid-resistantnephroticsyndrome.Method:60casesofpatientswi
5、thsteroid-resistantnephroticsyndromewererandomlydividedintotreatmentgroupandcontrolgroup,30casesinthecontrolgrouptobeclassicprednisonetherapyandTripterygiumtreatment;Treatmentgroups:controlgroupbasedontheuseShenqidihuangTangtaste.Patientsweretreatedforsixmonthstoobservet
6、hetwogroupsof24-hoururinaryproteinexcretion,Bloodlipids,Serumalbumin,andRenalfunction,Blood,Liverfunction,Blood,Urine,ECG,andTCMQiyinliangxunetworkstasisdampnesssymptomscorechanges,comparethedifferencesinefficacy.Results:Aftertreatment,patientswith24-hoururineprotein,Ser
7、umalbumin,Bloodlipids,Chinesemedicineclinicalsymptomscoresthanbeforetreatmentsuchasthereisaclearimprovement,significantdifferencesincomparisonwiththecontrolgroup.EffectofShenqidihuangdecoctiononblood,ECG,andliverfunctioninpatientswithnoadverseeffects.Conclusion:theeffect
8、ofshenqidihuangdecoctioncombinedwithTripterygiumtreatmentofsteroid-resistantnephroticsyndromewithsignif
