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ID:32840006
大小:11.17 MB
页数:61页
时间:2019-02-16
《wb-dwi联合常规ctmri在恶性肿瘤全身转移中的应用价值》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、泰山医学院硕士学位论文WB--DWI联合常规CT/MRI在恶性肿瘤全身转移中的应用价值姓名:刘辉申请学位级别:硕士专业:影像医学与核医学指导教师:李长勤2012-04wB.DwI联合常规CT/M埘在恶性肿瘤全身转移中的应用价值笼茎像茎蝴医学螋螋卿专业:影像医学与核医学V芝芝jIi懑主泛§。导师:李长勤教授中文摘要探讨全身弥散加权磁共振成像(wholebodydifmsion—weightedM对,WB—DwI)在正常人体不同组织器官及其联合常规CT,MRj诊断恶性肿瘤转移灶的临床应用价材料与方法对52例健康志愿者(男性25例,女性
2、27例)和76例恶性肿瘤患者(男性41例,女性35例)进行WB.DWI检查,其中76例恶性肿瘤患者均在7天内完成常规CT及MR检查,部分行增强扫描。采用双盲泫由两名资深影像医师对所有WB.DWI图像以及CT、MR图像进行分析。所有转移瘤均经手术或穿刺后病理学检查、影像学资料(cT、MⅪ或us)、实验室检查或随访至少3个月证实。统计正常成人不同组织器官的ADC值,比较腹部脏器ADC值有无差异及前列腺中央区、周缘区以及乳腺在不同年龄ADc值有无差异;统计单独应用wB—DwI和wB.DwI联合常规CT/M刚对转移瘤诊断的灵敏度、特异度和
3、准确度;比较两者在转移瘤的诊断中是否在b值等于600s/mm2时,正常成人脑皮质、脑白质、肝脏、脾脏、胰腺、肾脏、脊柱、淋巴结、前列腺中央区、前列腺周缘区、乳腺的ADC值分别为(单位:10。mm2/s)ADC值在<50岁组的人群中小于>50岁组的人群(P<0.05,P50岁组的人群(P<0.01)。单独应用WB—DwI诊断转移瘤的灵敏度为75.9%,特异度为25%,准确度为69.8%;wB—DwI联合cT/MRJ诊断转移瘤的灵敏度为94.8%,特异度为67.5%,准确度为91.5
4、%。经卡方检验,两者对恶性肿瘤全身转移灶的检出率具有统计学意义(P5、STASESFRoMMALIGNANTTUMORSPostgraduate:LiuHuiSpeciality:MedicaIImagingandNuclearMedicineSupenrisor:Pro£LiChang—qinABSTRACTobjectiveToexplorethevaluesof、vholebodydiffusion—wei曲tedM融(WB—DWI)andWB.DWIincombinationwithconventionalCT/M对inno胁alhumantissuesandorgansanddiagnos6、isofmetastasesofmalignanttumors.MaterialsandMethodsBoth52healtllyvolunteers(25maleand27female)and76patientswithmalignanttumors(41maleand35female)unde刑entWB—DWIexaminations.76patientswithmalignanttumorsu11derwentconventionalCTandMIUexaminations,fewofwhichundervventenha7、JlcedCTORM砒scaJl.‘rwoexperiencedimagingphysiciansanalyzedallofWB.DWI,CTandMRimagesbydouble-blindmethod.A11metastaseswereconfinnedbysu唱eryorpuncturepathology,imagingdata(CT,MⅪorUS)and1aborator),testsorfollow.upatleast3months.TheADCvaluesofnomaladulttissuesandorganswere8、calculated,comparedthedi舵rencesofTheADCvaluesinabdominalorgans,analyzedtherelevanceofageofprostatecentralzone,peripheralzone
5、STASESFRoMMALIGNANTTUMORSPostgraduate:LiuHuiSpeciality:MedicaIImagingandNuclearMedicineSupenrisor:Pro£LiChang—qinABSTRACTobjectiveToexplorethevaluesof、vholebodydiffusion—wei曲tedM融(WB—DWI)andWB.DWIincombinationwithconventionalCT/M对inno胁alhumantissuesandorgansanddiagnos
6、isofmetastasesofmalignanttumors.MaterialsandMethodsBoth52healtllyvolunteers(25maleand27female)and76patientswithmalignanttumors(41maleand35female)unde刑entWB—DWIexaminations.76patientswithmalignanttumorsu11derwentconventionalCTandMIUexaminations,fewofwhichundervventenha
7、JlcedCTORM砒scaJl.‘rwoexperiencedimagingphysiciansanalyzedallofWB.DWI,CTandMRimagesbydouble-blindmethod.A11metastaseswereconfinnedbysu唱eryorpuncturepathology,imagingdata(CT,MⅪorUS)and1aborator),testsorfollow.upatleast3months.TheADCvaluesofnomaladulttissuesandorganswere
8、calculated,comparedthedi舵rencesofTheADCvaluesinabdominalorgans,analyzedtherelevanceofageofprostatecentralzone,peripheralzone
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