肺结核患者维生素a、d营养状况及体外抑菌效果的分析

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1、Abstractobjective：ThisarticledetectedtheserumlevelsofvitaminAandDinpulmonarytuberculosispatientstounderstandthenutritionalstatusofvitaminsAandD，combinedwithantibacterialtesttolcamvitroantibacterialeffectofvitaminsAandD．Methods：152casesofpulmonarytuberculosispatientsweresel

2、ectedascasegroupand218healthypeopleofthesameareaasthecontrolgroup，thestudy’Sgeneralinformationincludingage，sex，heightandweightWascollectedbysurvey,andtheserumlevelsofvitaminAandDweredetectedbyhigh-performanceliquidchromatographyandliquidchromatography—tandemmassspectrometr

3、yrespectively．Furthermore，other18patients、析msputumculture-positivewereseclectedandthepositivestrainswerecultivatedandisolatedfromsputumforvitaminsAandDinterventionexperiments．Results：Theserul：nlevelsofvitaminAandDinthecasegroupwere1．73p,g／mland15．05ng／mlrespectively,whichw

4、erelowerthanthecontrolgroup1．93I_tg／mland17．00ng／ml，butonlythedifferenceinvitaminDWasstatisticallysignificant(P

5、lgroup2．75％，butthedifferenceWasnotstatisticallysignificant；TheVitaminDseriousdeficiencyinthecasegroupwas38．16％，whichWassignificantlyhigherthanthecontrolgroup21．56％(P<0．05)．ThereWasnosignificantdifferenceintheproportionofdeficiencyandplentybetweenthetwogroups．Thevitroantiba

6、cterialtestshowedthatcompared谢mthecontrolmedium，MTBcoloniesonthegroupsVA(VAl500IU／mL，VA21000IU／mL，VA32000IU／mL)mediumweresubjecttovaryingdegreesofinhibition,andthepositiveproportionofcolonygrowthwere92．37％，81．36％，86．44％respectively,whichwerealllessthanthecontrolmedium100％(

7、P

8、theVAlgroup7．63％，andtheinhibitoryeffectwasincreased(P